Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: Antiviral implications

Glial cells function as sensors for infection within the brain and produce cytokines to limit viral replication and spread. We examined both cytokine (TNF-alpha, IL-1beta, and IL-6) and chemokine (MCP-1, MIP-1alpha, RANTES, and IL-8) production by primary human glial cells in response to cytomegalov...

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Veröffentlicht in:	Journal of neurovirology 2001-04, Vol.7 (2), p.135-147
Hauptverfasser:	Cheeran, M C, Hu, S, Yager, S L, Gekker, G, Peterson, P K, Lokensgard, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes - cytology Astrocytes - immunology Astrocytes - virology Brain - cytology Brain - virology Cells, Cultured Chemokine CCL3 Chemokine CCL4 Chemokine CCL5 - genetics Chemokine CCL5 - immunology Chemotaxis - immunology Coculture Techniques Cytomegalovirus Cytomegalovirus - growth & development Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Encephalitis, Viral - immunology Encephalitis, Viral - virology Fetus - cytology Gene Expression Regulation, Viral - immunology Humans Interleukin-1 - genetics Interleukin-1 - immunology Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-8 - genetics Interleukin-8 - immunology macrophage inflammatory protein 1^a Macrophage Inflammatory Proteins - genetics Macrophage Inflammatory Proteins - immunology MCP-1 Microglia - cytology Microglia - immunology Microglia - virology RANTES RNA, Messenger - analysis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Virus Replication
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