Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog
Six dogs were diagnosed with protein‐losing enteropathy (PLE). There was no evidence of inappropriate inflammatory infiltrates or lymphangiectasia in multiple mucosal biopsies of the small intestine of 4 of the dogs. The 5th and 6th dogs had obvious lymphangiectasia and a moderate infiltrate of infl...
Gespeichert in:
| Veröffentlicht in: | Journal of veterinary internal medicine 2000-05, Vol.14 (3), p.298-307 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 307 |
|---|---|
| container_issue | 3 |
| container_start_page | 298 |
| container_title | Journal of veterinary internal medicine |
| container_volume | 14 |
| creator | Willard, M.D. Helman, G. Fradkin, J.M. Becker, T. Brown, R.M. Lewis, B.C. Weeks, B.R. |
| description | Six dogs were diagnosed with protein‐losing enteropathy (PLE). There was no evidence of inappropriate inflammatory infiltrates or lymphangiectasia in multiple mucosal biopsies of the small intestine of 4 of the dogs. The 5th and 6th dogs had obvious lymphangiectasia and a moderate infiltrate of inflammatory cells in the intestinal mucosa. All 6 dogs had a large number of dilated intestinal crypts that were filled with mucus, sloughed epithelial cells, and/or inflammatory cells. Whether PLE occurs in these dogs because of protein lost from the dilated crypts into the intestinal lumen or whether the dilated crypts are a mucosal reaction due to another undetermined lesion that is responsible for alimentary tract protein loss is unknown. However, when large numbers of dilated intestinal crypts are present, they appear to be associated with PLE even if there are no other remarkable lesions in the intestinal mucosa. |
| doi_str_mv | 10.1111/j.1939-1676.2000.tb01170.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_71150077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71150077</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3768-aed881334c0e4b42a45a17274ab09b26facbbb7d707af2be08be83d0c0765da63</originalsourceid><addsrcrecordid>eNqVkF1P2zAUhq0JNLqyv4CsXXCXcBwntsPNhDoGncKHEBu7s-zEpe7SuLNdtf33S5UK7RbfnAu_73N0HoS-EEhJ_y4WKSlpmRDGWZoBQBo1EMIh3X5Ao7evIzQCUZKEsRxO0KcQFgBZURT8IzohICgUeT5C99MumhBtp1o88btVxJUJ1nUBX4XgaquiafDGxjl-9C4a2yWVC7Z7xdd9z7uVivMdth2Oc4O_uddTdDxTbTCfD3OMfn6_fp7cJtXDzXRyVSU15UwkyjRCEErzGkyu80zlhSI847nSUOqMzVStteYNB65mmTYgtBG0gRo4KxrF6BidD9yVd3_X_QFyaUNt2lZ1xq2D5IQUAJz3wcshWHsXgjczufJ2qfxOEpB7m3Ih98rkXpnc25QHm3Lbl88OW9Z6aZr_qoO-PvB1CGxsa3bvQMsfv6Z3WSl6QjIQbIhm-0ZQ_o9knPJCvtzfyEr8fsnKJ5Cc_gPneJSj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71150077</pqid></control><display><type>article</type><title>Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog</title><source>Wiley Online Library Open Access</source><creator>Willard, M.D. ; Helman, G. ; Fradkin, J.M. ; Becker, T. ; Brown, R.M. ; Lewis, B.C. ; Weeks, B.R.</creator><creatorcontrib>Willard, M.D. ; Helman, G. ; Fradkin, J.M. ; Becker, T. ; Brown, R.M. ; Lewis, B.C. ; Weeks, B.R.</creatorcontrib><description>Six dogs were diagnosed with protein‐losing enteropathy (PLE). There was no evidence of inappropriate inflammatory infiltrates or lymphangiectasia in multiple mucosal biopsies of the small intestine of 4 of the dogs. The 5th and 6th dogs had obvious lymphangiectasia and a moderate infiltrate of inflammatory cells in the intestinal mucosa. All 6 dogs had a large number of dilated intestinal crypts that were filled with mucus, sloughed epithelial cells, and/or inflammatory cells. Whether PLE occurs in these dogs because of protein lost from the dilated crypts into the intestinal lumen or whether the dilated crypts are a mucosal reaction due to another undetermined lesion that is responsible for alimentary tract protein loss is unknown. However, when large numbers of dilated intestinal crypts are present, they appear to be associated with PLE even if there are no other remarkable lesions in the intestinal mucosa.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.2000.tb01170.x</identifier><identifier>PMID: 10830544</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biopsy - veterinary ; Dog Diseases - pathology ; Dogs ; Endoscopy, Gastrointestinal - veterinary ; Female ; Gastroduodenoscopy ; Hypoalbuminemia ; Hypoproteinemia - pathology ; Hypoproteinemia - veterinary ; Intestinal biopsy ; Intestinal Mucosa - pathology ; Lymphangiectasia ; Lymphangiectasis, Intestinal - pathology ; Lymphangiectasis, Intestinal - veterinary ; Male ; Protein-Losing Enteropathies - pathology ; Protein-Losing Enteropathies - veterinary</subject><ispartof>Journal of veterinary internal medicine, 2000-05, Vol.14 (3), p.298-307</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3768-aed881334c0e4b42a45a17274ab09b26facbbb7d707af2be08be83d0c0765da63</citedby><cites>FETCH-LOGICAL-c3768-aed881334c0e4b42a45a17274ab09b26facbbb7d707af2be08be83d0c0765da63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.2000.tb01170.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.2000.tb01170.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.2000.tb01170.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10830544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willard, M.D.</creatorcontrib><creatorcontrib>Helman, G.</creatorcontrib><creatorcontrib>Fradkin, J.M.</creatorcontrib><creatorcontrib>Becker, T.</creatorcontrib><creatorcontrib>Brown, R.M.</creatorcontrib><creatorcontrib>Lewis, B.C.</creatorcontrib><creatorcontrib>Weeks, B.R.</creatorcontrib><title>Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Six dogs were diagnosed with protein‐losing enteropathy (PLE). There was no evidence of inappropriate inflammatory infiltrates or lymphangiectasia in multiple mucosal biopsies of the small intestine of 4 of the dogs. The 5th and 6th dogs had obvious lymphangiectasia and a moderate infiltrate of inflammatory cells in the intestinal mucosa. All 6 dogs had a large number of dilated intestinal crypts that were filled with mucus, sloughed epithelial cells, and/or inflammatory cells. Whether PLE occurs in these dogs because of protein lost from the dilated crypts into the intestinal lumen or whether the dilated crypts are a mucosal reaction due to another undetermined lesion that is responsible for alimentary tract protein loss is unknown. However, when large numbers of dilated intestinal crypts are present, they appear to be associated with PLE even if there are no other remarkable lesions in the intestinal mucosa.</description><subject>Animals</subject><subject>Biopsy - veterinary</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Endoscopy, Gastrointestinal - veterinary</subject><subject>Female</subject><subject>Gastroduodenoscopy</subject><subject>Hypoalbuminemia</subject><subject>Hypoproteinemia - pathology</subject><subject>Hypoproteinemia - veterinary</subject><subject>Intestinal biopsy</subject><subject>Intestinal Mucosa - pathology</subject><subject>Lymphangiectasia</subject><subject>Lymphangiectasis, Intestinal - pathology</subject><subject>Lymphangiectasis, Intestinal - veterinary</subject><subject>Male</subject><subject>Protein-Losing Enteropathies - pathology</subject><subject>Protein-Losing Enteropathies - veterinary</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1P2zAUhq0JNLqyv4CsXXCXcBwntsPNhDoGncKHEBu7s-zEpe7SuLNdtf33S5UK7RbfnAu_73N0HoS-EEhJ_y4WKSlpmRDGWZoBQBo1EMIh3X5Ao7evIzQCUZKEsRxO0KcQFgBZURT8IzohICgUeT5C99MumhBtp1o88btVxJUJ1nUBX4XgaquiafDGxjl-9C4a2yWVC7Z7xdd9z7uVivMdth2Oc4O_uddTdDxTbTCfD3OMfn6_fp7cJtXDzXRyVSU15UwkyjRCEErzGkyu80zlhSI847nSUOqMzVStteYNB65mmTYgtBG0gRo4KxrF6BidD9yVd3_X_QFyaUNt2lZ1xq2D5IQUAJz3wcshWHsXgjczufJ2qfxOEpB7m3Ih98rkXpnc25QHm3Lbl88OW9Z6aZr_qoO-PvB1CGxsa3bvQMsfv6Z3WSl6QjIQbIhm-0ZQ_o9knPJCvtzfyEr8fsnKJ5Cc_gPneJSj</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Willard, M.D.</creator><creator>Helman, G.</creator><creator>Fradkin, J.M.</creator><creator>Becker, T.</creator><creator>Brown, R.M.</creator><creator>Lewis, B.C.</creator><creator>Weeks, B.R.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog</title><author>Willard, M.D. ; Helman, G. ; Fradkin, J.M. ; Becker, T. ; Brown, R.M. ; Lewis, B.C. ; Weeks, B.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3768-aed881334c0e4b42a45a17274ab09b26facbbb7d707af2be08be83d0c0765da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biopsy - veterinary</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Endoscopy, Gastrointestinal - veterinary</topic><topic>Female</topic><topic>Gastroduodenoscopy</topic><topic>Hypoalbuminemia</topic><topic>Hypoproteinemia - pathology</topic><topic>Hypoproteinemia - veterinary</topic><topic>Intestinal biopsy</topic><topic>Intestinal Mucosa - pathology</topic><topic>Lymphangiectasia</topic><topic>Lymphangiectasis, Intestinal - pathology</topic><topic>Lymphangiectasis, Intestinal - veterinary</topic><topic>Male</topic><topic>Protein-Losing Enteropathies - pathology</topic><topic>Protein-Losing Enteropathies - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willard, M.D.</creatorcontrib><creatorcontrib>Helman, G.</creatorcontrib><creatorcontrib>Fradkin, J.M.</creatorcontrib><creatorcontrib>Becker, T.</creatorcontrib><creatorcontrib>Brown, R.M.</creatorcontrib><creatorcontrib>Lewis, B.C.</creatorcontrib><creatorcontrib>Weeks, B.R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Willard, M.D.</au><au>Helman, G.</au><au>Fradkin, J.M.</au><au>Becker, T.</au><au>Brown, R.M.</au><au>Lewis, B.C.</au><au>Weeks, B.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2000-05</date><risdate>2000</risdate><volume>14</volume><issue>3</issue><spage>298</spage><epage>307</epage><pages>298-307</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Six dogs were diagnosed with protein‐losing enteropathy (PLE). There was no evidence of inappropriate inflammatory infiltrates or lymphangiectasia in multiple mucosal biopsies of the small intestine of 4 of the dogs. The 5th and 6th dogs had obvious lymphangiectasia and a moderate infiltrate of inflammatory cells in the intestinal mucosa. All 6 dogs had a large number of dilated intestinal crypts that were filled with mucus, sloughed epithelial cells, and/or inflammatory cells. Whether PLE occurs in these dogs because of protein lost from the dilated crypts into the intestinal lumen or whether the dilated crypts are a mucosal reaction due to another undetermined lesion that is responsible for alimentary tract protein loss is unknown. However, when large numbers of dilated intestinal crypts are present, they appear to be associated with PLE even if there are no other remarkable lesions in the intestinal mucosa.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10830544</pmid><doi>10.1111/j.1939-1676.2000.tb01170.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0891-6640 |
| ispartof | Journal of veterinary internal medicine, 2000-05, Vol.14 (3), p.298-307 |
| issn | 0891-6640 1939-1676 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71150077 |
| source | Wiley Online Library Open Access |
| subjects | Animals Biopsy - veterinary Dog Diseases - pathology Dogs Endoscopy, Gastrointestinal - veterinary Female Gastroduodenoscopy Hypoalbuminemia Hypoproteinemia - pathology Hypoproteinemia - veterinary Intestinal biopsy Intestinal Mucosa - pathology Lymphangiectasia Lymphangiectasis, Intestinal - pathology Lymphangiectasis, Intestinal - veterinary Male Protein-Losing Enteropathies - pathology Protein-Losing Enteropathies - veterinary |
| title | Intestinal Crypt Lesions Associated with Protein-Losing Enteropathy in the Dog |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T15%3A01%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intestinal%20Crypt%20Lesions%20Associated%20with%20Protein-Losing%20Enteropathy%20in%20the%20Dog&rft.jtitle=Journal%20of%20veterinary%20internal%20medicine&rft.au=Willard,%20M.D.&rft.date=2000-05&rft.volume=14&rft.issue=3&rft.spage=298&rft.epage=307&rft.pages=298-307&rft.issn=0891-6640&rft.eissn=1939-1676&rft_id=info:doi/10.1111/j.1939-1676.2000.tb01170.x&rft_dat=%3Cproquest_24P%3E71150077%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71150077&rft_id=info:pmid/10830544&rfr_iscdi=true |