A Soluble Dominant Negative Fibroblast Growth Factor Receptor 4 Isoform in Human MCF-7 Breast Cancer Cells

Fibroblast growth factor receptors (FGFRs) are receptor tyrosine kinases encoded by four closely related genes. FGFR 1, 2, and 3 have a number of isoforms derived by alternative splicing, alternative initiation and exon switching; however, FGFR4 has been reported to encode a single intact receptor w...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-09, Vol.287 (1), p.60-65
Hauptverfasser:	Ezzat, Shereen, Zheng, Lei, Yu, ShunJiang, Asa, Sylvia L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Female FGF Fibroblast Growth Factor 1 Fibroblast Growth Factor 2 - metabolism fibroblast growth factor receptor 4 fibroblast growth factor receptor-4 isoforms Gene Deletion Humans Introns - genetics Mice Molecular Sequence Data PRL gene Protein Isoforms - genetics Protein Isoforms - metabolism Protein Isoforms - pharmacology Receptor, Fibroblast Growth Factor, Type 4 Receptors, Fibroblast Growth Factor - antagonists & inhibitors Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism RNA Splicing Solubility soluble dominant negative receptors Tumor Cells, Cultured
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