Human umbilical vein: involvement of cyclooxygenase-2 pathway in bradykinin B1 receptor-sensitized responses

In isolated human umbilical vein (HUV), the contractile response to des-Arg9-bradykinin (des-Arg9-BK), selective BK B1 receptor agonist, increases as a function of the incubation time. Here, we evaluated whether cyclooxygenase (COX) pathway is involved in BK B1-sensitized response obtained in 5-h in...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2001-08, Vol.364 (2), p.149-156
Hauptverfasser:	Errasti, A E, Rey-Ares, V, Daray, F M, Rogines-Velo, M P, Sardi, S P, Paz, C, Podestá, E J, Rothlin, R P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bradykinin - analogs & derivatives Bradykinin - pharmacology Cyclooxygenase 2 Dose-Response Relationship, Drug Humans Isoenzymes - physiology Isometric Contraction - drug effects Isometric Contraction - physiology Membrane Proteins Organ Culture Techniques Prostaglandin-Endoperoxide Synthases - physiology Receptor, Bradykinin B1 Receptor, Bradykinin B2 Receptors, Bradykinin - agonists Receptors, Bradykinin - physiology Signal Transduction - drug effects Signal Transduction - physiology Umbilical Veins - drug effects Umbilical Veins - enzymology Umbilical Veins - metabolism Vasoconstriction - drug effects Vasoconstriction - physiology
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