Kinetics of a Model Nucleoside (Guanosine) Release from Biodegradable Poly(dl-lactide-co-glycolide) Microspheres: A Delivery System for Long-Term Intraocular Delivery

The objective of this study was to prepare poly(dl-lactide-co-glycolide)(PLGA) microspheres containing guanosine as a model drug for intraocular administration. Microspheres were prepared by solvent evaporation technique using o w emulsion system. The influence of composition and molecular weight of...

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Veröffentlicht in:	Pharmaceutical development and technology 2000, Vol.5 (2), p.279-285
Hauptverfasser:	Chowdhury, Dipak K., Mitra, Ashim K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Buffers Chemical Phenomena Chemistry, Physical Dextrans Drug Carriers Drug Delivery Systems Fluorescein-5-isothiocyanate - analogs & derivatives Guanosine - administration & dosage Guanosine - chemistry Guanosine - pharmacokinetics In vitro-in vivo correlation Kinetics Lactic Acid Male Microdialysis Microspheres Ophthalmic Solutions Particle Size Phosphates Poly(DL-lactide-co-glycolide) Polyglycolic Acid Polymers Rabbits Release rates Solubility Surface Properties Vitreous Body - chemistry Vitreous Body - metabolism Vitreous fluid
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