Induction of cytokine mRNA in peripheral blood mononuclear cells of infants after the first dose of measles vaccine
To better characterize the cytokine response to measles virus vaccine, we examined the levels of IL-2, IL-4, IL-5, IL-10, IL-12 and γ-interferon (γ-IFN) in measles virus-stimulated peripheral blood mononuclear cells from 18 donors before and 2 weeks after vaccination. Donors were grouped as seroposi...
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| Veröffentlicht in: | Vaccine 2001-09, Vol.19 (32), p.4896-4900 |
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| creator | Li, H. Hickman, C.J. Helfand, R.F. Keyserling, H. Anderson, L.J. Bellini, W.J. |
| description | To better characterize the cytokine response to measles virus vaccine, we examined the levels of IL-2, IL-4, IL-5, IL-10, IL-12 and γ-interferon (γ-IFN) in measles virus-stimulated peripheral blood mononuclear cells from 18 donors before and 2 weeks after vaccination. Donors were grouped as seropositive or seronegative on the basis of measles-specific IgM antibody present at 2 weeks postvaccination. After vaccination, similar levels of upregulation of IL-2 and γ-IFN mRNA were observed in the two groups. The majority of donors in both groups did not exhibit an increase in measles specific IL-4 or IL-10 mRNA after vaccination. IL-12 mRNA was not induced by measles virus in any of the donors. A statistically significant upregulation of IL-5 mRNA was observed among seropositive (9/13) compared with seronegative (1/5) donors after vaccination (
P=0.09, one tailed Fisher's test). The observed measles specific induction of IL-5 mRNA is suggestive of a possible association between IL-5 production and an antibody response to measles virus. |
| doi_str_mv | 10.1016/S0264-410X(01)00227-4 |
| format | Article |
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P=0.09, one tailed Fisher's test). The observed measles specific induction of IL-5 mRNA is suggestive of a possible association between IL-5 production and an antibody response to measles virus.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(01)00227-4</identifier><identifier>PMID: 11535343</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Antibodies, Viral - biosynthesis ; Antibodies, Viral - blood ; Biological and medical sciences ; Cytokine ; Epidemiology. Vaccinations ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; g-Interferon ; Gene Expression Regulation ; General aspects ; Humans ; Immunity, Cellular ; Immunobiology ; Immunoglobulin M - biosynthesis ; Immunoglobulin M - blood ; Infant ; Infants ; Infectious diseases ; Interferon-gamma - biosynthesis ; Interferon-gamma - genetics ; Interleukin-10 - biosynthesis ; Interleukin-10 - genetics ; Interleukin-12 - biosynthesis ; Interleukin-12 - genetics ; Interleukin-2 - biosynthesis ; Interleukin-2 - genetics ; Interleukin-4 - biosynthesis ; Interleukin-4 - genetics ; Interleukin-5 - biosynthesis ; Interleukin-5 - genetics ; Interleukins - biosynthesis ; Interleukins - genetics ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Lymphocyte Activation - genetics ; Lymphocyte Activation - immunology ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Male ; Measles ; Measles Vaccine - immunology ; Measles virus ; Measles virus - immunology ; Medical sciences ; peripheral blood mononuclear cells ; Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; Vaccination</subject><ispartof>Vaccine, 2001-09, Vol.19 (32), p.4896-4900</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-bf8adc52b37e28576900b53691ef54b026ee5e11659d0d936189d4a20a394ea3</citedby><cites>FETCH-LOGICAL-c422t-bf8adc52b37e28576900b53691ef54b026ee5e11659d0d936189d4a20a394ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X01002274$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14153901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11535343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, H.</creatorcontrib><creatorcontrib>Hickman, C.J.</creatorcontrib><creatorcontrib>Helfand, R.F.</creatorcontrib><creatorcontrib>Keyserling, H.</creatorcontrib><creatorcontrib>Anderson, L.J.</creatorcontrib><creatorcontrib>Bellini, W.J.</creatorcontrib><title>Induction of cytokine mRNA in peripheral blood mononuclear cells of infants after the first dose of measles vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>To better characterize the cytokine response to measles virus vaccine, we examined the levels of IL-2, IL-4, IL-5, IL-10, IL-12 and γ-interferon (γ-IFN) in measles virus-stimulated peripheral blood mononuclear cells from 18 donors before and 2 weeks after vaccination. Donors were grouped as seropositive or seronegative on the basis of measles-specific IgM antibody present at 2 weeks postvaccination. After vaccination, similar levels of upregulation of IL-2 and γ-IFN mRNA were observed in the two groups. The majority of donors in both groups did not exhibit an increase in measles specific IL-4 or IL-10 mRNA after vaccination. IL-12 mRNA was not induced by measles virus in any of the donors. A statistically significant upregulation of IL-5 mRNA was observed among seropositive (9/13) compared with seronegative (1/5) donors after vaccination (
P=0.09, one tailed Fisher's test). The observed measles specific induction of IL-5 mRNA is suggestive of a possible association between IL-5 production and an antibody response to measles virus.</description><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Cytokine</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>g-Interferon</subject><subject>Gene Expression Regulation</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunobiology</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunoglobulin M - blood</subject><subject>Infant</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-12 - biosynthesis</subject><subject>Interleukin-12 - genetics</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Interleukin-2 - genetics</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Interleukin-4 - genetics</subject><subject>Interleukin-5 - biosynthesis</subject><subject>Interleukin-5 - genetics</subject><subject>Interleukins - biosynthesis</subject><subject>Interleukins - genetics</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lymphocyte Activation - genetics</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</subject><subject>Male</subject><subject>Measles</subject><subject>Measles Vaccine - immunology</subject><subject>Measles virus</subject><subject>Measles virus - immunology</subject><subject>Medical sciences</subject><subject>peripheral blood mononuclear cells</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Vaccination</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EorcXfgLIGxAsUjx-5LFCVUVppQok6IKd5dgT1ZDYF9up1H_fpPeqXXY1i_nOPM4h5B2wE2BQf_nNeC0rCezPJwafGeO8qeQLsoG2ERVX0L4km0fkiBzn_JcxpgR0r8kRgBJKSLEh-TK42RYfA40DtXcl_vMB6fTrxyn1ge4w-d0NJjPSfozR0SmGGGY7oknU4jjmVebDYELJ1AwFEy03SAefcqEuZlz7E5o8Yqa3xtpl-hvyajBjxreHuiXX59-uzy6qq5_fL89OryorOS9VP7TGWcV70SBvVVN3jPVK1B3goGS_PIeoEKBWnWOuEzW0nZOGMyM6iUZsycf92F2K_2fMRU8-rzebgHHOugGQTb3Y9RwILQCvF8O2RO1Bm2LOCQe9S34y6U4D02sq-iEVvVquGeiHVLRcdO8PC-Z-QvekOsSwAB8OgMnWjEMywfr8xMkF7Bgs3Nc9h4tttx6TztZjsOh8Qlu0i_6ZU-4BQ52poA</recordid><startdate>20010914</startdate><enddate>20010914</enddate><creator>Li, H.</creator><creator>Hickman, C.J.</creator><creator>Helfand, R.F.</creator><creator>Keyserling, H.</creator><creator>Anderson, L.J.</creator><creator>Bellini, W.J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010914</creationdate><title>Induction of cytokine mRNA in peripheral blood mononuclear cells of infants after the first dose of measles vaccine</title><author>Li, H. ; Hickman, C.J. ; Helfand, R.F. ; Keyserling, H. ; Anderson, L.J. ; Bellini, W.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-bf8adc52b37e28576900b53691ef54b026ee5e11659d0d936189d4a20a394ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antibodies, Viral - biosynthesis</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Cytokine</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>g-Interferon</topic><topic>Gene Expression Regulation</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunobiology</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunoglobulin M - blood</topic><topic>Infant</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-12 - biosynthesis</topic><topic>Interleukin-12 - genetics</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Interleukin-2 - genetics</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Interleukin-4 - genetics</topic><topic>Interleukin-5 - biosynthesis</topic><topic>Interleukin-5 - genetics</topic><topic>Interleukins - biosynthesis</topic><topic>Interleukins - genetics</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lymphocyte Activation - genetics</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</topic><topic>Male</topic><topic>Measles</topic><topic>Measles Vaccine - immunology</topic><topic>Measles virus</topic><topic>Measles virus - immunology</topic><topic>Medical sciences</topic><topic>peripheral blood mononuclear cells</topic><topic>Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, H.</creatorcontrib><creatorcontrib>Hickman, C.J.</creatorcontrib><creatorcontrib>Helfand, R.F.</creatorcontrib><creatorcontrib>Keyserling, H.</creatorcontrib><creatorcontrib>Anderson, L.J.</creatorcontrib><creatorcontrib>Bellini, W.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, H.</au><au>Hickman, C.J.</au><au>Helfand, R.F.</au><au>Keyserling, H.</au><au>Anderson, L.J.</au><au>Bellini, W.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of cytokine mRNA in peripheral blood mononuclear cells of infants after the first dose of measles vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2001-09-14</date><risdate>2001</risdate><volume>19</volume><issue>32</issue><spage>4896</spage><epage>4900</epage><pages>4896-4900</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>To better characterize the cytokine response to measles virus vaccine, we examined the levels of IL-2, IL-4, IL-5, IL-10, IL-12 and γ-interferon (γ-IFN) in measles virus-stimulated peripheral blood mononuclear cells from 18 donors before and 2 weeks after vaccination. Donors were grouped as seropositive or seronegative on the basis of measles-specific IgM antibody present at 2 weeks postvaccination. After vaccination, similar levels of upregulation of IL-2 and γ-IFN mRNA were observed in the two groups. The majority of donors in both groups did not exhibit an increase in measles specific IL-4 or IL-10 mRNA after vaccination. IL-12 mRNA was not induced by measles virus in any of the donors. A statistically significant upregulation of IL-5 mRNA was observed among seropositive (9/13) compared with seronegative (1/5) donors after vaccination (
P=0.09, one tailed Fisher's test). The observed measles specific induction of IL-5 mRNA is suggestive of a possible association between IL-5 production and an antibody response to measles virus.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11535343</pmid><doi>10.1016/S0264-410X(01)00227-4</doi><tpages>5</tpages></addata></record> |
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| subjects | Antibodies, Viral - biosynthesis Antibodies, Viral - blood Biological and medical sciences Cytokine Epidemiology. Vaccinations Female Fundamental and applied biological sciences. Psychology Fundamental immunology g-Interferon Gene Expression Regulation General aspects Humans Immunity, Cellular Immunobiology Immunoglobulin M - biosynthesis Immunoglobulin M - blood Infant Infants Infectious diseases Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-12 - biosynthesis Interleukin-12 - genetics Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Interleukin-5 - biosynthesis Interleukin-5 - genetics Interleukins - biosynthesis Interleukins - genetics Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Measles Measles Vaccine - immunology Measles virus Measles virus - immunology Medical sciences peripheral blood mononuclear cells Polymerase Chain Reaction RNA, Messenger - biosynthesis Vaccination |
| title | Induction of cytokine mRNA in peripheral blood mononuclear cells of infants after the first dose of measles vaccine |
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