Desmethyl tirilazad improves neurologic function after hypoxic ischemic brain injury in piglets

OBJECTIVE:Desmethyl tirilazad is a lipid-soluble free radical quencher. Deferoxamine reduces free radicals by chelating iron and reducing hydroxyl formation. Free radical inhibitors have shown promise in several hypoxic ischemic brain injury models, and we wished to see if this work could be extende...

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Veröffentlicht in:	Critical care medicine 2000-05, Vol.28 (5), p.1431-1438
Hauptverfasser:	Feng, Yangzheng, LeBlanc, Michael H, LeBlanc, Eric B, Parker, Colette C, Fratkin, Jonathan D, Qian, Xiao-Bing, Patel, Daksha M, Huang, Min, Smith, Edward E, Vig, Parminder J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antioxidants - pharmacology Asphyxia Neonatorum - pathology Asphyxia Neonatorum - physiopathology Brain - blood supply Brain - pathology Deferoxamine - pharmacology Dose-Response Relationship, Drug Humans Hypoxia, Brain - pathology Hypoxia, Brain - physiopathology Infant, Newborn Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Neurologic Examination - drug effects Pregnatrienes - pharmacology Reactive Oxygen Species - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology Swine
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