Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4

Heparan sulfate-regulated transmembrane tyrosine kinase receptor FGFR4 is the major FGFR isotype in mature hepatocytes. Fibroblast growth factor has been implicated in the definition of liver from foregut endoderm where FGFR4 is expressed and stimulation of hepatocyte DNA synthesis in vitro. Here we...

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Veröffentlicht in:	The Journal of biological chemistry 2000-05, Vol.275 (20), p.15482-15489
Hauptverfasser:	Yu, Chundong, Wang, Fen, Kan, Mikio, Jin, Chengliu, Jones, Richard B., Weinstein, Michael, Deng, Chu-Xia, McKeehan, Wallace L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - biosynthesis Cell Membrane - metabolism cholate Cholesterol - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Gallbladder - metabolism Gallbladder - pathology Gene Expression Regulation, Enzymologic Heparan sulfate Hepatectomy Hydroxymethylglutaryl CoA Reductases - genetics Liver - cytology Liver - physiology Liver Regeneration Mice Mice, Knockout receptor interacting protein 140 Receptor Protein-Tyrosine Kinases - deficiency Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 4 receptor-tyrosine kinase Receptors, Fibroblast Growth Factor - deficiency Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - physiology
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