Anxiety as a Correlate of Response to the Acute Treatment of Bipolar I Disorder
OBJECTIVE: Given the adverse impact of anxiety on treatment outcome in unipolar depression and the paucity of data on the role of anxiety in bipolar disorder, the authors sought to determine the effect of anxiety on the acute treatment response of patients with bipolar I disorder.METHOD: The authors...
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| Veröffentlicht in: | The American journal of psychiatry 2000-06, Vol.157 (6), p.956-962 |
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| container_title | The American journal of psychiatry |
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| creator | Feske, Ulrike Frank, Ellen Mallinger, Alan G. Houck, Patricia R. Fagiolini, Andrea Shear, M. Katherine Grochocinski, Victoria J. Kupfer, David J. |
| description | OBJECTIVE: Given the adverse impact of anxiety on treatment outcome in unipolar depression and the paucity of data on the role of anxiety in bipolar disorder, the authors sought to determine the effect of anxiety on the acute treatment response of patients with bipolar I disorder.METHOD: The authors examined the correlates of response to the acute treatment of 124 consecutively treated patients with bipolar I disorder. Measures of anxiety included history of panic attacks and a composite variable reflecting current or past anxiety symptoms.RESULTS: History of panic attacks proved to be a significant correlate of nonremission. Anxiety, as assessed with the composite variable, was associated with longer time to remission, as was the treatment of depressive versus manic symptoms and mixed versus manic symptoms. Patients with anxiety as assessed with the composite variable and patients with a history of panic attacks reported more severe medication side effects. They also required a greater number of medications, either sequentially or in combination, in order to achieve remission.CONCLUSIONS: The findings suggest that anxiety is a clinically meaningful correlate of poor outcome in the acute treatment of bipolar I disorder. |
| doi_str_mv | 10.1176/appi.ajp.157.6.956 |
| format | Article |
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Katherine ; Grochocinski, Victoria J. ; Kupfer, David J.</creator><creatorcontrib>Feske, Ulrike ; Frank, Ellen ; Mallinger, Alan G. ; Houck, Patricia R. ; Fagiolini, Andrea ; Shear, M. Katherine ; Grochocinski, Victoria J. ; Kupfer, David J.</creatorcontrib><description>OBJECTIVE: Given the adverse impact of anxiety on treatment outcome in unipolar depression and the paucity of data on the role of anxiety in bipolar disorder, the authors sought to determine the effect of anxiety on the acute treatment response of patients with bipolar I disorder.METHOD: The authors examined the correlates of response to the acute treatment of 124 consecutively treated patients with bipolar I disorder. Measures of anxiety included history of panic attacks and a composite variable reflecting current or past anxiety symptoms.RESULTS: History of panic attacks proved to be a significant correlate of nonremission. Anxiety, as assessed with the composite variable, was associated with longer time to remission, as was the treatment of depressive versus manic symptoms and mixed versus manic symptoms. Patients with anxiety as assessed with the composite variable and patients with a history of panic attacks reported more severe medication side effects. They also required a greater number of medications, either sequentially or in combination, in order to achieve remission.CONCLUSIONS: The findings suggest that anxiety is a clinically meaningful correlate of poor outcome in the acute treatment of bipolar I disorder.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.157.6.956</identifier><identifier>PMID: 10831476</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Anxiety ; Anxiety Disorders - diagnosis ; Anxiety Disorders - epidemiology ; Bipolar Disorder - diagnosis ; Bipolar Disorder - epidemiology ; Bipolar Disorder - therapy ; Combined Modality Therapy ; Comorbidity ; Correlation analysis ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Humans ; Manic depression ; Middle Aged ; Panic Disorder - diagnosis ; Panic Disorder - epidemiology ; Patient Compliance ; Prevalence ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychiatry ; Psychotherapy ; Psychotropic Drugs - administration & dosage ; Psychotropic Drugs - therapeutic use ; Remission Induction ; Therapy ; Treatment Outcome</subject><ispartof>The American journal of psychiatry, 2000-06, Vol.157 (6), p.956-962</ispartof><rights>Copyright American Psychiatric Association Jun 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a394t-55dcc7123cb42dd4454b904ca7255b8e0394ddc5ef4a06541812eb3236b96daf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.157.6.956$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.157.6.956$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2841,21606,21607,21608,27848,27903,27904,77541,77546</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10831476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feske, Ulrike</creatorcontrib><creatorcontrib>Frank, Ellen</creatorcontrib><creatorcontrib>Mallinger, Alan G.</creatorcontrib><creatorcontrib>Houck, Patricia R.</creatorcontrib><creatorcontrib>Fagiolini, Andrea</creatorcontrib><creatorcontrib>Shear, M. Katherine</creatorcontrib><creatorcontrib>Grochocinski, Victoria J.</creatorcontrib><creatorcontrib>Kupfer, David J.</creatorcontrib><title>Anxiety as a Correlate of Response to the Acute Treatment of Bipolar I Disorder</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Given the adverse impact of anxiety on treatment outcome in unipolar depression and the paucity of data on the role of anxiety in bipolar disorder, the authors sought to determine the effect of anxiety on the acute treatment response of patients with bipolar I disorder.METHOD: The authors examined the correlates of response to the acute treatment of 124 consecutively treated patients with bipolar I disorder. Measures of anxiety included history of panic attacks and a composite variable reflecting current or past anxiety symptoms.RESULTS: History of panic attacks proved to be a significant correlate of nonremission. Anxiety, as assessed with the composite variable, was associated with longer time to remission, as was the treatment of depressive versus manic symptoms and mixed versus manic symptoms. Patients with anxiety as assessed with the composite variable and patients with a history of panic attacks reported more severe medication side effects. They also required a greater number of medications, either sequentially or in combination, in order to achieve remission.CONCLUSIONS: The findings suggest that anxiety is a clinically meaningful correlate of poor outcome in the acute treatment of bipolar I disorder.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Anxiety Disorders - diagnosis</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar Disorder - therapy</subject><subject>Combined Modality Therapy</subject><subject>Comorbidity</subject><subject>Correlation analysis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Humans</subject><subject>Manic depression</subject><subject>Middle Aged</subject><subject>Panic Disorder - diagnosis</subject><subject>Panic Disorder - epidemiology</subject><subject>Patient Compliance</subject><subject>Prevalence</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Psychiatry</subject><subject>Psychotherapy</subject><subject>Psychotropic Drugs - administration & dosage</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Remission Induction</subject><subject>Therapy</subject><subject>Treatment Outcome</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kV1LwzAUhoMoOqd_wAsJCt61y3fayzk_QRiIgnchbU-xo2tq0oL-ezMnKIJX4ZDnfU_Ig9AJJSmlWs1s3zepXfUplTpVaS7VDppQyWWiGct20YQQwpJc8pcDdBjCKo6Ea7aPDijJOBVaTdBy3r03MHxgG7DFC-c9tHYA7Gr8CKF3XQA8ODy8Ap6XY7x48mCHNXTDBrlsetdaj-_xVROcr8Afob3atgGOv88per65flrcJQ_L2_vF_CGxPBdDImVVlpoyXhaCVZUQUhQ5EaXVTMoiAxKpqiol1MISJQXNKIOCM66KXFW25lN0se3tvXsbIQxm3YQS2tZ24MZgNKVCCUEjePYHXLnRd_FthjEiFONZHqHz_yAqacZ1LuLXTRHbUqV3IXioTe-btfUfhhKzMWI2Rkw0ElPaKBONxNDpd_VYrKH6FdkqiMBsC3yFf_b-X_kJemaWMg</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Feske, Ulrike</creator><creator>Frank, Ellen</creator><creator>Mallinger, Alan G.</creator><creator>Houck, Patricia R.</creator><creator>Fagiolini, Andrea</creator><creator>Shear, M. Katherine</creator><creator>Grochocinski, Victoria J.</creator><creator>Kupfer, David J.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Anxiety as a Correlate of Response to the Acute Treatment of Bipolar I Disorder</title><author>Feske, Ulrike ; Frank, Ellen ; Mallinger, Alan G. ; Houck, Patricia R. ; Fagiolini, Andrea ; Shear, M. Katherine ; Grochocinski, Victoria J. ; Kupfer, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a394t-55dcc7123cb42dd4454b904ca7255b8e0394ddc5ef4a06541812eb3236b96daf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Anxiety Disorders - diagnosis</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar Disorder - therapy</topic><topic>Combined Modality Therapy</topic><topic>Comorbidity</topic><topic>Correlation analysis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Humans</topic><topic>Manic depression</topic><topic>Middle Aged</topic><topic>Panic Disorder - diagnosis</topic><topic>Panic Disorder - epidemiology</topic><topic>Patient Compliance</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Psychiatry</topic><topic>Psychotherapy</topic><topic>Psychotropic Drugs - administration & dosage</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>Remission Induction</topic><topic>Therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feske, Ulrike</creatorcontrib><creatorcontrib>Frank, Ellen</creatorcontrib><creatorcontrib>Mallinger, Alan G.</creatorcontrib><creatorcontrib>Houck, Patricia R.</creatorcontrib><creatorcontrib>Fagiolini, Andrea</creatorcontrib><creatorcontrib>Shear, M. 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Katherine</au><au>Grochocinski, Victoria J.</au><au>Kupfer, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiety as a Correlate of Response to the Acute Treatment of Bipolar I Disorder</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>157</volume><issue>6</issue><spage>956</spage><epage>962</epage><pages>956-962</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Given the adverse impact of anxiety on treatment outcome in unipolar depression and the paucity of data on the role of anxiety in bipolar disorder, the authors sought to determine the effect of anxiety on the acute treatment response of patients with bipolar I disorder.METHOD: The authors examined the correlates of response to the acute treatment of 124 consecutively treated patients with bipolar I disorder. Measures of anxiety included history of panic attacks and a composite variable reflecting current or past anxiety symptoms.RESULTS: History of panic attacks proved to be a significant correlate of nonremission. Anxiety, as assessed with the composite variable, was associated with longer time to remission, as was the treatment of depressive versus manic symptoms and mixed versus manic symptoms. Patients with anxiety as assessed with the composite variable and patients with a history of panic attacks reported more severe medication side effects. They also required a greater number of medications, either sequentially or in combination, in order to achieve remission.CONCLUSIONS: The findings suggest that anxiety is a clinically meaningful correlate of poor outcome in the acute treatment of bipolar I disorder.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>10831476</pmid><doi>10.1176/appi.ajp.157.6.956</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Periodicals Index Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Anxiety Anxiety Disorders - diagnosis Anxiety Disorders - epidemiology Bipolar Disorder - diagnosis Bipolar Disorder - epidemiology Bipolar Disorder - therapy Combined Modality Therapy Comorbidity Correlation analysis Dose-Response Relationship, Drug Drug Administration Schedule Humans Manic depression Middle Aged Panic Disorder - diagnosis Panic Disorder - epidemiology Patient Compliance Prevalence Psychiatric Status Rating Scales - statistics & numerical data Psychiatry Psychotherapy Psychotropic Drugs - administration & dosage Psychotropic Drugs - therapeutic use Remission Induction Therapy Treatment Outcome |
| title | Anxiety as a Correlate of Response to the Acute Treatment of Bipolar I Disorder |
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