Oblique Membrane Insertion of Viral Fusion Peptide Probed by Neutron Diffraction

Fusion peptides mimic the membrane fusion activities of the larger viral proteins from which they derive their sequences. A possible mode of activity involves their oblique insertion into lipid bilayers, causing membrane disruption by promoting highly curved hemifusion intermediates, leading to fusi...

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Veröffentlicht in:	Biochemistry (Easton) 2000-06, Vol.39 (22), p.6581-6585
Hauptverfasser:	Bradshaw, Jeremy P, Darkes, Malcolm J. M, Harroun, Thad A, Katsaras, John, Epand, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Deuterium Fourier Analysis Lipid Bilayers - chemistry Membrane Lipids - chemistry Models, Molecular Neutrons Peptides - chemistry Phospholipids - chemistry Protein Structure, Secondary Scattering, Radiation Simian immunodeficiency virus Simian Immunodeficiency Virus - chemistry Viral Fusion Proteins - chemistry
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