Protein delivery from materials formed by self-selective conjugate addition reactions

A new chemical cross-linking scheme was utilized for the formation of degradable poly(ethylene glycol) hydrogels suitable for the delivery of protein drugs. An aqueous solution containing a PEG-multiacrylate and solid particles of albumin was mixed with an aqueous solution containing a PEG-dithiol,...

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Veröffentlicht in:	Journal of controlled release 2001-09, Vol.76 (1), p.11-25
Hauptverfasser:	Elbert, Donald L, Pratt, Alison B, Lutolf, Matthias P, Halstenberg, Sven, Hubbell, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - administration & dosage Biological and medical sciences Conjugate addition Drug Delivery Systems General pharmacology Hydrogel Hydrogels Medical sciences Michael-type addition Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(ethylene glycol) Polyethylene Glycols - administration & dosage Protein delivery Proteins - administration & dosage
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