Pituitary Adenylyl Cyclase-activating Peptide Activates Multiple Intracellular Signaling Pathways to Regulate Ion Channels in PC12 Cells

Pituitary adenylyl cyclase-activating peptide (PACAP) stimulates calcium transients and catecholamine secretion in adrenal chromaffin and PC12 cells. The PACAP type 1 receptor in these cells couples to both adenylyl cyclase and phospolipase C pathways, but although phospolipase C has been implicated...

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Veröffentlicht in:	The Journal of biological chemistry 2000-06, Vol.275 (22), p.16626-16631
Hauptverfasser:	Osipenko, Oleg N., Barrie, Anne P., Allen, Janet M., Gurney, Alison M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Calcium Channels - metabolism Calcium Channels - physiology Guanosine 5'-O-(3-Thiotriphosphate) - physiology Membrane Potentials - physiology Neuropeptides - metabolism Neuropeptides - physiology Oncogene Protein p21(ras) - physiology PC12 Cells Pituitary Adenylate Cyclase-Activating Polypeptide Rats Signal Transduction - physiology Type C Phospholipases - metabolism
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