FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development

We investigated the mechanism of tissue induction and specification using the lacrimal gland as a model system. This structure begins its morphogenesis as a bud-like outgrowth of the conjunctival epithelium and ultimately forms a branched structure with secretory function. Using a reporter transgene...

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Veröffentlicht in:	Development (Cambridge) 2000-06, Vol.127 (12), p.2563-2572
Hauptverfasser:	Makarenkova, H P, Ito, M, Govindarajan, V, Faber, S C, Sun, L, McMahon, G, Overbeek, P A, Lang, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - physiology Epithelium - embryology Eye Proteins - physiology FGF10 gene Fibroblast Growth Factor 10 Fibroblast Growth Factor 2 - physiology Fibroblast Growth Factor 7 Fibroblast Growth Factors - deficiency Fibroblast Growth Factors - genetics Fibroblast Growth Factors - physiology Growth Substances - physiology Homeodomain Proteins Lacrimal Apparatus - embryology lacrimal gland Mesoderm - cytology Mesoderm - physiology Mice Mice, Knockout Morphogenesis Organ Culture Techniques Paired Box Transcription Factors Pax6 gene PAX6 Transcription Factor Repressor Proteins Signal Transduction
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