The significance of bcr-abl molecular detection in chronic myeloid leukemia patients “late,” 18 months or more after transplantation

The bcr-abl chimeric messenger RNA is frequently detected in chronic myeloid leukemia (CML) patients after bone marrow transplantation. It was previously reported that the relapse risk of bcr-abl detection 6 to 12 months after transplantation was greater than 40%. This risk decreased as the time bet...

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Veröffentlicht in:	Blood 2001-09, Vol.98 (6), p.1701-1707
Hauptverfasser:	Radich, Jerald P., Gooley, Ted, Bryant, Eileen, Chauncey, Tom, Clift, Reginald, Beppu, Lan, Edmands, Scott, Flowers, Mary E.D., Kerkof, Keith, Nelson, Ross, Appelbaum, Frederick R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Bone Marrow Transplantation Child Child, Preschool Female Fusion Proteins, bcr-abl - biosynthesis Fusion Proteins, bcr-abl - genetics Hematologic and hematopoietic diseases Humans Kinetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neoplasm Recurrence, Local Risk Factors RNA, Neoplasm - biosynthesis
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