Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase

Gold compounds are used in the treatment of rheumatoid arthritis. NF-kappa B is a transcription factor implicated in the expression of many inflammatory genes. NF-kappa B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory I kappa B (inhibitory protein that dissoc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2000-06, Vol.164 (11), p.5981-5989
Hauptverfasser:	Jeon, K I, Jeong, J Y, Jue, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Auranofin - pharmacology Cell Line Copper - pharmacology Enzyme Activation - drug effects Enzyme Activation - immunology Enzyme Inhibitors - pharmacology Gold Compounds - pharmacology HeLa Cells Humans I-kappa B Kinase I^KB protein IKK protein Lipopolysaccharides - pharmacology Metals, Heavy - metabolism Metals, Heavy - pharmacology Mice NF-^KB protein NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - metabolism Sulfhydryl Compounds - metabolism Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis U937 Cells Zinc - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!