Impact of bile acid malabsorption on steatorrhoea and symptoms in patients with chronic diarrhoea
OBJECTIVE DESIGN METHODS RESULTSForty-two patients had a SeHCAT value < 10%. Mild steatorrhoea was common in patients with nonorganic bile acid malabsorption (50%) and in patients with functional diarrhoea (38%). There was no correlation between low SeHCAT values and steatorrhoea, although some p...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2000-05, Vol.12 (5), p.541-548 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Ung, Kjell-Arne Kilander, Anders F Lindgren, Anders Abrahamsson, Hasse |
| description | OBJECTIVE
DESIGN
METHODS
RESULTSForty-two patients had a SeHCAT value < 10%. Mild steatorrhoea was common in patients with nonorganic bile acid malabsorption (50%) and in patients with functional diarrhoea (38%). There was no correlation between low SeHCAT values and steatorrhoea, although some patients with severe organic disease had a concomitant malabsorption of fat and of bile acids. In coeliac disease, severe steatorrhoea was common even in patients with high SeHCAT values. Patients with bile acid malabsorption had more frequent (P < 0.008) and looser (P = 0.0021) stools compared with patients with functional diarrhoea. There was no difference in abdominal pain, distension or flatulence.
CONCLUSIONMild steatorrhoea is common in both nonorganic bile acid malabsorption and functional diarrhoea. The SeHCAT value cannot predict the risk of steatorrhoea. The high prevalence of bile acid malabsorption in patients with chronic diarrhoea and the absence of specific symptoms, except frequent and more liquid stools, indicates that the SeHCAT test should be performed early in the investigation of these patients. Eur J Gastroenterol Hepatol 12:541-547 |
| doi_str_mv | 10.1097/00042737-200012050-00011 |
| format | Article |
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DESIGN
METHODS
RESULTSForty-two patients had a SeHCAT value < 10%. Mild steatorrhoea was common in patients with nonorganic bile acid malabsorption (50%) and in patients with functional diarrhoea (38%). There was no correlation between low SeHCAT values and steatorrhoea, although some patients with severe organic disease had a concomitant malabsorption of fat and of bile acids. In coeliac disease, severe steatorrhoea was common even in patients with high SeHCAT values. Patients with bile acid malabsorption had more frequent (P < 0.008) and looser (P = 0.0021) stools compared with patients with functional diarrhoea. There was no difference in abdominal pain, distension or flatulence.
CONCLUSIONMild steatorrhoea is common in both nonorganic bile acid malabsorption and functional diarrhoea. The SeHCAT value cannot predict the risk of steatorrhoea. The high prevalence of bile acid malabsorption in patients with chronic diarrhoea and the absence of specific symptoms, except frequent and more liquid stools, indicates that the SeHCAT test should be performed early in the investigation of these patients. Eur J Gastroenterol Hepatol 12:541-547</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/00042737-200012050-00011</identifier><identifier>PMID: 10833098</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bile Acids and Salts - metabolism ; Biological and medical sciences ; Celiac Disease - complications ; Chronic Disease ; Colonic Diseases, Functional - etiology ; Colonic Diseases, Functional - physiopathology ; Diarrhea - etiology ; Diarrhea - physiopathology ; Feces - chemistry ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Malabsorption Syndromes - complications ; Malabsorption Syndromes - diagnostic imaging ; Malabsorption Syndromes - metabolism ; Malabsorption Syndromes - physiopathology ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Prospective Studies ; Radionuclide Imaging ; Statistics, Nonparametric ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>European journal of gastroenterology & hepatology, 2000-05, Vol.12 (5), p.541-548</ispartof><rights>2000 Lippincott Williams & Wilkins, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3851-5d7ced4b0231effe86070ece190306b9810c13dc2725e1480d0aa3df7e41e3f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1360611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10833098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ung, Kjell-Arne</creatorcontrib><creatorcontrib>Kilander, Anders F</creatorcontrib><creatorcontrib>Lindgren, Anders</creatorcontrib><creatorcontrib>Abrahamsson, Hasse</creatorcontrib><title>Impact of bile acid malabsorption on steatorrhoea and symptoms in patients with chronic diarrhoea</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVE
DESIGN
METHODS
RESULTSForty-two patients had a SeHCAT value < 10%. Mild steatorrhoea was common in patients with nonorganic bile acid malabsorption (50%) and in patients with functional diarrhoea (38%). There was no correlation between low SeHCAT values and steatorrhoea, although some patients with severe organic disease had a concomitant malabsorption of fat and of bile acids. In coeliac disease, severe steatorrhoea was common even in patients with high SeHCAT values. Patients with bile acid malabsorption had more frequent (P < 0.008) and looser (P = 0.0021) stools compared with patients with functional diarrhoea. There was no difference in abdominal pain, distension or flatulence.
CONCLUSIONMild steatorrhoea is common in both nonorganic bile acid malabsorption and functional diarrhoea. The SeHCAT value cannot predict the risk of steatorrhoea. The high prevalence of bile acid malabsorption in patients with chronic diarrhoea and the absence of specific symptoms, except frequent and more liquid stools, indicates that the SeHCAT test should be performed early in the investigation of these patients. Eur J Gastroenterol Hepatol 12:541-547</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>Celiac Disease - complications</subject><subject>Chronic Disease</subject><subject>Colonic Diseases, Functional - etiology</subject><subject>Colonic Diseases, Functional - physiopathology</subject><subject>Diarrhea - etiology</subject><subject>Diarrhea - physiopathology</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Malabsorption Syndromes - complications</subject><subject>Malabsorption Syndromes - diagnostic imaging</subject><subject>Malabsorption Syndromes - metabolism</subject><subject>Malabsorption Syndromes - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prospective Studies</subject><subject>Radionuclide Imaging</subject><subject>Statistics, Nonparametric</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV2L1TAQhoMo7tnVvyC5EO-6zjRp017K4sfCgjcK3oVpOqXRtqlJDof993a3x48bYWDm4nln4BkhJMI1QmveAoAujTJFuU1YQgXFw4BPxAG1UUVVN-apOEBb6aJu8duFuEzp-0YYhea5uEBolIK2OQi6nVdyWYZBdn5iSc73cqaJuhTimn1Y5FYpM-UQ4xiYJC29TPfzmsOcpF_kStnzkpM8-TxKN8aweCd7Tzv_QjwbaEr88tyvxNcP77_cfCruPn-8vXl3VzjVVFhUvXHc6w5KhTwM3NRggB1jCwrqrm0QHKrelaasGHUDPRCpfjCskdXQqCvxZt-7xvDzyCnb2SfH00QLh2OyBlGjLtsNbHbQxZBS5MGu0c8U7y2CfdBrf-u1f_TaR71b9NX5xrGbuf8nuPvcgNdngJKjaYi0OJ_-cqqG-nGP3rFTmDLH9GM6njjakWnKo_3fd9UvrfaSlg</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Ung, Kjell-Arne</creator><creator>Kilander, Anders F</creator><creator>Lindgren, Anders</creator><creator>Abrahamsson, Hasse</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>Impact of bile acid malabsorption on steatorrhoea and symptoms in patients with chronic diarrhoea</title><author>Ung, Kjell-Arne ; Kilander, Anders F ; Lindgren, Anders ; Abrahamsson, Hasse</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3851-5d7ced4b0231effe86070ece190306b9810c13dc2725e1480d0aa3df7e41e3f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biological and medical sciences</topic><topic>Celiac Disease - complications</topic><topic>Chronic Disease</topic><topic>Colonic Diseases, Functional - etiology</topic><topic>Colonic Diseases, Functional - physiopathology</topic><topic>Diarrhea - etiology</topic><topic>Diarrhea - physiopathology</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Malabsorption Syndromes - complications</topic><topic>Malabsorption Syndromes - diagnostic imaging</topic><topic>Malabsorption Syndromes - metabolism</topic><topic>Malabsorption Syndromes - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prospective Studies</topic><topic>Radionuclide Imaging</topic><topic>Statistics, Nonparametric</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ung, Kjell-Arne</creatorcontrib><creatorcontrib>Kilander, Anders F</creatorcontrib><creatorcontrib>Lindgren, Anders</creatorcontrib><creatorcontrib>Abrahamsson, Hasse</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ung, Kjell-Arne</au><au>Kilander, Anders F</au><au>Lindgren, Anders</au><au>Abrahamsson, Hasse</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of bile acid malabsorption on steatorrhoea and symptoms in patients with chronic diarrhoea</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2000-05</date><risdate>2000</risdate><volume>12</volume><issue>5</issue><spage>541</spage><epage>548</epage><pages>541-548</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVE
DESIGN
METHODS
RESULTSForty-two patients had a SeHCAT value < 10%. Mild steatorrhoea was common in patients with nonorganic bile acid malabsorption (50%) and in patients with functional diarrhoea (38%). There was no correlation between low SeHCAT values and steatorrhoea, although some patients with severe organic disease had a concomitant malabsorption of fat and of bile acids. In coeliac disease, severe steatorrhoea was common even in patients with high SeHCAT values. Patients with bile acid malabsorption had more frequent (P < 0.008) and looser (P = 0.0021) stools compared with patients with functional diarrhoea. There was no difference in abdominal pain, distension or flatulence.
CONCLUSIONMild steatorrhoea is common in both nonorganic bile acid malabsorption and functional diarrhoea. The SeHCAT value cannot predict the risk of steatorrhoea. The high prevalence of bile acid malabsorption in patients with chronic diarrhoea and the absence of specific symptoms, except frequent and more liquid stools, indicates that the SeHCAT test should be performed early in the investigation of these patients. Eur J Gastroenterol Hepatol 12:541-547</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10833098</pmid><doi>10.1097/00042737-200012050-00011</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bile Acids and Salts - metabolism Biological and medical sciences Celiac Disease - complications Chronic Disease Colonic Diseases, Functional - etiology Colonic Diseases, Functional - physiopathology Diarrhea - etiology Diarrhea - physiopathology Feces - chemistry Female Gastroenterology. Liver. Pancreas. Abdomen Humans Malabsorption Syndromes - complications Malabsorption Syndromes - diagnostic imaging Malabsorption Syndromes - metabolism Malabsorption Syndromes - physiopathology Male Medical sciences Middle Aged Other diseases. Semiology Prospective Studies Radionuclide Imaging Statistics, Nonparametric Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Impact of bile acid malabsorption on steatorrhoea and symptoms in patients with chronic diarrhoea |
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