A Glucocorticoid Receptor Gene Marker Is Associated with Abdominal Obesity, Leptin, and Dysregulation of the Hypothalamic‐Pituitary‐Adrenal Axis

Objective: Abdominal obesity has a key role in the pathogenesis of prevalent and serious diseases and has been shown to be associated with an altered hypothalamic‐pituitary‐adrenal (HPA) axis function, which is regulated by endocrine feedback mediated via hippocampal glucocorticoid receptors (GR). R...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2000-05, Vol.8 (3), p.211-218
Hauptverfasser:	Rosmond, Roland, Chagnon, Yvon C., Holm, Göran, Chagnon, Monique, Pérusse, Louis, Lindell, Kajsa, Carlsson, Björn, Bouchard, Claude, Björntorp, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	abdominal obesity Adipose Tissue - physiopathology Alleles Blood Glucose - analysis Blood Pressure Body Constitution Body Mass Index Cohort Studies cortisol Dexamethasone - pharmacology DNA - chemistry DNA - isolation & purification Eukaryotic Initiation Factor-1 - blood glucocorticoid receptors Glucocorticoids - pharmacology Humans Hydrocortisone - secretion Hypothalamo-Hypophyseal System - physiopathology Insulin - analysis leptin Leptin - blood Male metabolic syndrome Middle Aged Obesity - blood Obesity - epidemiology Obesity - genetics Pituitary-Adrenal System - physiopathology Polymorphism, Restriction Fragment Length Receptors, Glucocorticoid - chemistry Receptors, Glucocorticoid - genetics Salivary Glands - secretion Sweden - epidemiology Testosterone - blood
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