Estrogen receptor α mediated induction of the transforming growth factor α gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells

The selective estrogen receptor modulator, 4-hydroxytamoxifen (4-OHT) is a full agonist at the transforming growth factor (TGF) α gene in ER negative breast cancer cells stably transfected with ERα cDNA (Levenson et al., Br. J. Cancer 77 (1998) 1812–1819). E 2 and 4-OHT increase TGFα mRNA and protei...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2001-07, Vol.78 (1), p.41-50
Hauptverfasser:	MacGregor Schafer, Jennifer, Liu, Hong, Levenson, Anait S., Horiguchi, Jun, Chen, Zehan, Jordan, V.Craig
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxytamoxifen Antiestrogen Biological and medical sciences Blotting, Northern Blotting, Western Breast cancer Cycloheximide - pharmacology Dactinomycin - analogs & derivatives Dactinomycin - pharmacology DNA, Complementary - metabolism Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Estradiol - pharmacology Estrogen Antagonists Estrogen Receptor alpha Estrogen Receptor beta Hormones. Endocrine system Humans Luciferases - metabolism Medical sciences Pharmacology. Drug treatments Protein Synthesis Inhibitors - pharmacology Receptors, Estrogen - biosynthesis Receptors, Estrogen - metabolism RNA, Messenger - metabolism Signal Transduction Tamoxifen - analogs & derivatives Tamoxifen - pharmacology TGFα Time Factors Transcription, Genetic Transfection Transforming Growth Factor alpha - metabolism Tumor Cells, Cultured
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