Novel bioadhesive delivery system for percutaneous local anaesthesia
We have assessed the efficacy of a novel bioadhesive amethocaine patch device, compared to Ametop gel, in a randomized, double-blinded trial. Patch and gel formulations, including placebos, were applied to the forearms of volunteers (n = 30) for 40 min. Once the formulations were removed from the sk...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2000-04, Vol.84 (4), p.456-458 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | McCafferty, D F Woolfson, A D Moss, G P |
| description | We have assessed the efficacy of a novel bioadhesive amethocaine patch device, compared to Ametop gel, in a randomized, double-blinded trial. Patch and gel formulations, including placebos, were applied to the forearms of volunteers (n = 30) for 40 min. Once the formulations were removed from the skin, anaesthesia was assessed by volunteers using a conventional pinprick test. Pain scores were recorded for 4 h after removal of gels and patches. Statistical analysis of the results indicated that both amethocaine gel and patch preparations were superior to placebo (P < 0.05). No significant difference was observed between amethocaine gel and patch formulations (P > 0.05) in either onset time or duration of action for percutaneous local anaesthesia. The results of this study indicate therefore that the novel bioadhesive patch provides clinically comparable anaesthesia to the established gel formulation in a more defined dosage form. |
| doi_str_mv | 10.1093/oxfordjournals.bja.a013469 |
| format | Article |
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Patch and gel formulations, including placebos, were applied to the forearms of volunteers (n = 30) for 40 min. Once the formulations were removed from the skin, anaesthesia was assessed by volunteers using a conventional pinprick test. Pain scores were recorded for 4 h after removal of gels and patches. Statistical analysis of the results indicated that both amethocaine gel and patch preparations were superior to placebo (P < 0.05). No significant difference was observed between amethocaine gel and patch formulations (P > 0.05) in either onset time or duration of action for percutaneous local anaesthesia. The results of this study indicate therefore that the novel bioadhesive patch provides clinically comparable anaesthesia to the established gel formulation in a more defined dosage form.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/oxfordjournals.bja.a013469</identifier><identifier>PMID: 10823095</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Cutaneous ; Adult ; Anesthetics, Local - administration & dosage ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Cross-Over Studies ; Double-Blind Method ; Female ; Gels ; Humans ; Male ; Medical sciences ; Neuropharmacology ; Pain Measurement - drug effects ; Pharmacology. 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Patch and gel formulations, including placebos, were applied to the forearms of volunteers (n = 30) for 40 min. Once the formulations were removed from the skin, anaesthesia was assessed by volunteers using a conventional pinprick test. Pain scores were recorded for 4 h after removal of gels and patches. Statistical analysis of the results indicated that both amethocaine gel and patch preparations were superior to placebo (P < 0.05). No significant difference was observed between amethocaine gel and patch formulations (P > 0.05) in either onset time or duration of action for percutaneous local anaesthesia. The results of this study indicate therefore that the novel bioadhesive patch provides clinically comparable anaesthesia to the established gel formulation in a more defined dosage form.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gels</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pain Measurement - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Tetracaine - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFO3DAQhi1UBFvgFaoIVdyyjOMkjnuroC1ICC7t2ZrYE9WrbLy1kxX79hhlEaWnchqN9P3zjz7GzjksOShx6R87H-zKT2HAPi7bFS4RuChrdcAWvJQ8r6XkH9gCAGQOihfH7GOMKwAuC1UdsWMOTSFAVQt2fe-31Get82h_U3Rbyiz1aYRdFndxpHWWyrINBTONOJCfYtZ7g32GA1IcnzN4yg679Amd7ecJ-_X928-rm_zu4cft1de73FQCxlzUgipAECViWVhZpFWquu06tLIxSIZ3KK1p05e2qKgUylphZENNR8IqccIu5rub4P9MqV2vXTTU9_NjWnIu6qaCBJ7_A77Y0lzJhqukMUFfZsgEH2OgTm-CW2PYaQ76WbR-K1on0XovOoU_7Rumdk32r-hsNgGf9wDGpKsLOBgXXzkBjVJlwqoZ89Pmff3Xc46S762joKNxNBiyLpAZtfXuf848AQqbuTw</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>McCafferty, D F</creator><creator>Woolfson, A D</creator><creator>Moss, G P</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Novel bioadhesive delivery system for percutaneous local anaesthesia</title><author>McCafferty, D F ; Woolfson, A D ; Moss, G P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-363e50a034aa42d723e5796bffad78caec1fa7dcb729d25e439dd3c78e8fe3d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gels</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pain Measurement - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Tetracaine - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCafferty, D F</creatorcontrib><creatorcontrib>Woolfson, A D</creatorcontrib><creatorcontrib>Moss, G P</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCafferty, D F</au><au>Woolfson, A D</au><au>Moss, G P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel bioadhesive delivery system for percutaneous local anaesthesia</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>84</volume><issue>4</issue><spage>456</spage><epage>458</epage><pages>456-458</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have assessed the efficacy of a novel bioadhesive amethocaine patch device, compared to Ametop gel, in a randomized, double-blinded trial. 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| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 2000-04, Vol.84 (4), p.456-458 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Cutaneous Adult Anesthetics, Local - administration & dosage Anesthetics. Neuromuscular blocking agents Biological and medical sciences Cross-Over Studies Double-Blind Method Female Gels Humans Male Medical sciences Neuropharmacology Pain Measurement - drug effects Pharmacology. Drug treatments Tetracaine - administration & dosage Treatment Outcome |
| title | Novel bioadhesive delivery system for percutaneous local anaesthesia |
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