Synthesis and α-Adrenergic Binding Ligand Affinities of 2-Iminoimidazolidine Derivatives

In order to obtain possible veinotonic drugs acting through α2 receptor activation, we prepared clonidine analogues in which the 2-imino-imidazolidine was attached to various aliphatic or aromatic heterocycles. Among them, the two benzopyranic derivatives 16 and 22 exhibited interesting affinities (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 2000/05/01, Vol.48(5), pp.729-733
Hauptverfasser:	FONG, Jean Chang, BENAMOUR, Khalid, SZYMONSKI, Barbara, THOMASSON, Francois, MORAND, Jean-Marc, CUSSAC, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists - chemical synthesis Adrenergic alpha-Agonists - metabolism Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - metabolism adrenergic α2-ligand Animals Binding, Competitive - drug effects Biological and medical sciences Cardiovascular system Catecholaminergic system Clonidine - metabolism Idazoxan - analogs & derivatives Idazoxan - metabolism Imidazoles - chemical synthesis Imidazoles - pharmacology imidazolidine derivative In Vitro Techniques Ligands Magnetic Resonance Spectroscopy Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Prazosin - metabolism Rats Receptors, Adrenergic, alpha-2 - metabolism Spectrophotometry, Infrared veinotonic agent Yohimbine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!