PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways

Vascular endothelial growth factor (VEGF) plays an essential role in the initiation and regulation of angiogenesis-a crucial component of wound healing and cancer growth. Prostaglandins (PGs) stimulate angiogenesis but the precise mechanisms of their pro-angiogenic actions remain unexplained. We inv...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-09, Vol.286 (5), p.923-928
Hauptverfasser:	Pai, R, Szabo, I L, Soreghan, B A, Atay, S, Kawanaka, H, Tarnawski, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cells, Cultured Culture Media, Serum-Free - pharmacology Dinoprostone - metabolism Dose-Response Relationship, Drug Endothelial Growth Factors - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Enzyme Activation Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Lymphokines - metabolism Microcirculation Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth - cytology Neovascularization, Pathologic Rats Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Signal Transduction Time Factors Transcriptional Activation Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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