Fargosides A-E, Triterpenoid Saponins from Holboellia fargesii
Five new triterpenoid saponins, fargosides A, B, C, D, and E, were isolated from the roots of Holboellia fargesii. The structures of fargosides A-E were elucidated on the basis of chemical and physicochemical evidence and found to be 3β, 20α-dihydroxy-29-norolean-12-en-28-oic acid 3-O-β-D-xylopyrano...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2001, Vol.49(8), pp.999-1002 |
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| creator | FU, Hongzheng KOIKE, Kazuo ZHENG, Quan MITSUNAGA, Katsuyoshi JIA, Zhonghua NIKAIDO, Tamotsu LIN, Wenhan GUO, Dean ZHANG, Lihe |
| description | Five new triterpenoid saponins, fargosides A, B, C, D, and E, were isolated from the roots of Holboellia fargesii. The structures of fargosides A-E were elucidated on the basis of chemical and physicochemical evidence and found to be 3β, 20α-dihydroxy-29-norolean-12-en-28-oic acid 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside (1), 3β, 20α, 24-trihydroxy-29-norolean-12-en-28-oic acid 23-O-β-D-fucopyranosyl-(1→2)-[α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside (2), 3β, 23-dihydroxy-30-norolean-2, 20(29)-dien-28-oic acid 3-O-α-L-arabinopyranosyl-(1→2)-[β-D-glucopyranosyluronic acid-(1→3)]-α-L-arabinopyranoside (3), 3β, 23-dihydroxy-30-norolean-12, 20(29)-dien-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (4), and 3β, 23-dihydroxy-olean-12-en-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (5), respectively. |
| doi_str_mv | 10.1248/cpb.49.999 |
| format | Article |
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The structures of fargosides A-E were elucidated on the basis of chemical and physicochemical evidence and found to be 3β, 20α-dihydroxy-29-norolean-12-en-28-oic acid 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside (1), 3β, 20α, 24-trihydroxy-29-norolean-12-en-28-oic acid 23-O-β-D-fucopyranosyl-(1→2)-[α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside (2), 3β, 23-dihydroxy-30-norolean-2, 20(29)-dien-28-oic acid 3-O-α-L-arabinopyranosyl-(1→2)-[β-D-glucopyranosyluronic acid-(1→3)]-α-L-arabinopyranoside (3), 3β, 23-dihydroxy-30-norolean-12, 20(29)-dien-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (4), and 3β, 23-dihydroxy-olean-12-en-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (5), respectively.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.49.999</identifier><identifier>PMID: 11515592</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Biological and medical sciences ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - isolation & purification ; General pharmacology ; Holboellia fargesii ; Lardizabalaceae ; Medical sciences ; Medicine, Chinese Traditional ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. 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Drug treatments ; Plants, Medicinal - chemistry ; Saponins - chemistry ; Saponins - isolation & purification ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; triterpenoid saponin</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2001, Vol.49(8), pp.999-1002</ispartof><rights>2001 The Pharmaceutical Society of Japan</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-23cfeb6e8cc78cad381d5fc3564ff89d8d7bfa20479763899dc758a03d50deec3</citedby><cites>FETCH-LOGICAL-c579t-23cfeb6e8cc78cad381d5fc3564ff89d8d7bfa20479763899dc758a03d50deec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1133144$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11515592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FU, Hongzheng</creatorcontrib><creatorcontrib>KOIKE, Kazuo</creatorcontrib><creatorcontrib>ZHENG, Quan</creatorcontrib><creatorcontrib>MITSUNAGA, Katsuyoshi</creatorcontrib><creatorcontrib>JIA, Zhonghua</creatorcontrib><creatorcontrib>NIKAIDO, Tamotsu</creatorcontrib><creatorcontrib>LIN, Wenhan</creatorcontrib><creatorcontrib>GUO, Dean</creatorcontrib><creatorcontrib>ZHANG, Lihe</creatorcontrib><title>Fargosides A-E, Triterpenoid Saponins from Holboellia fargesii</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Five new triterpenoid saponins, fargosides A, B, C, D, and E, were isolated from the roots of Holboellia fargesii. The structures of fargosides A-E were elucidated on the basis of chemical and physicochemical evidence and found to be 3β, 20α-dihydroxy-29-norolean-12-en-28-oic acid 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside (1), 3β, 20α, 24-trihydroxy-29-norolean-12-en-28-oic acid 23-O-β-D-fucopyranosyl-(1→2)-[α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside (2), 3β, 23-dihydroxy-30-norolean-2, 20(29)-dien-28-oic acid 3-O-α-L-arabinopyranosyl-(1→2)-[β-D-glucopyranosyluronic acid-(1→3)]-α-L-arabinopyranoside (3), 3β, 23-dihydroxy-30-norolean-12, 20(29)-dien-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (4), and 3β, 23-dihydroxy-olean-12-en-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (5), respectively.</description><subject>Biological and medical sciences</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>General pharmacology</subject><subject>Holboellia fargesii</subject><subject>Lardizabalaceae</subject><subject>Medical sciences</subject><subject>Medicine, Chinese Traditional</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Saponins - chemistry</subject><subject>Saponins - isolation & purification</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>triterpenoid saponin</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M9vFCEUB3BiNHZbvfgHmEk0HoyzwjwY4FLTNK1t0qQH65kw8KhsZocRZg_978Xs2ppe4PA-70e-hLxjdM06rr66eVhzvdZavyArBly2ouvgJVlRSnXbQQ9H5LiUDaWdoBJekyPGBBNCdytyemnzfSrRY2nO2osvzV2OC-YZpxR988POaYpTaUJO2-YqjUPCcYy2CbULS4xvyKtgx4JvD_8J-Xl5cXd-1d7cfr8-P7tpnZB6qTe4gEOPyjmpnPWgmBfBgeh5CEp75eUQbEe51LIHpbV3UihLwQvqER2ckE_7uXNOv3dYFrONxdVb7IRpV4xkDEB0UOGHZ3CTdnmqtxnGewqgpWRVfd4rl1MpGYOZc9za_GAYNX8zNTVTw7WpmVb8_jByN2zRP9FDiBV8PABbnB1DtpOL5T8HwDiv7Nuebcpi7_GxbvMS3Yj_Vqr9Uzc_VX7ZbHCCP_HnlJI</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>FU, Hongzheng</creator><creator>KOIKE, Kazuo</creator><creator>ZHENG, Quan</creator><creator>MITSUNAGA, Katsuyoshi</creator><creator>JIA, Zhonghua</creator><creator>NIKAIDO, Tamotsu</creator><creator>LIN, Wenhan</creator><creator>GUO, Dean</creator><creator>ZHANG, Lihe</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Fargosides A-E, Triterpenoid Saponins from Holboellia fargesii</title><author>FU, Hongzheng ; KOIKE, Kazuo ; ZHENG, Quan ; MITSUNAGA, Katsuyoshi ; JIA, Zhonghua ; NIKAIDO, Tamotsu ; LIN, Wenhan ; GUO, Dean ; ZHANG, Lihe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-23cfeb6e8cc78cad381d5fc3564ff89d8d7bfa20479763899dc758a03d50deec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>General pharmacology</topic><topic>Holboellia fargesii</topic><topic>Lardizabalaceae</topic><topic>Medical sciences</topic><topic>Medicine, Chinese Traditional</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Saponins - chemistry</topic><topic>Saponins - isolation & purification</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>triterpenoid saponin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FU, Hongzheng</creatorcontrib><creatorcontrib>KOIKE, Kazuo</creatorcontrib><creatorcontrib>ZHENG, Quan</creatorcontrib><creatorcontrib>MITSUNAGA, Katsuyoshi</creatorcontrib><creatorcontrib>JIA, Zhonghua</creatorcontrib><creatorcontrib>NIKAIDO, Tamotsu</creatorcontrib><creatorcontrib>LIN, Wenhan</creatorcontrib><creatorcontrib>GUO, Dean</creatorcontrib><creatorcontrib>ZHANG, Lihe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FU, Hongzheng</au><au>KOIKE, Kazuo</au><au>ZHENG, Quan</au><au>MITSUNAGA, Katsuyoshi</au><au>JIA, Zhonghua</au><au>NIKAIDO, Tamotsu</au><au>LIN, Wenhan</au><au>GUO, Dean</au><au>ZHANG, Lihe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fargosides A-E, Triterpenoid Saponins from Holboellia fargesii</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>49</volume><issue>8</issue><spage>999</spage><epage>1002</epage><pages>999-1002</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Five new triterpenoid saponins, fargosides A, B, C, D, and E, were isolated from the roots of Holboellia fargesii. The structures of fargosides A-E were elucidated on the basis of chemical and physicochemical evidence and found to be 3β, 20α-dihydroxy-29-norolean-12-en-28-oic acid 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside (1), 3β, 20α, 24-trihydroxy-29-norolean-12-en-28-oic acid 23-O-β-D-fucopyranosyl-(1→2)-[α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside (2), 3β, 23-dihydroxy-30-norolean-2, 20(29)-dien-28-oic acid 3-O-α-L-arabinopyranosyl-(1→2)-[β-D-glucopyranosyluronic acid-(1→3)]-α-L-arabinopyranoside (3), 3β, 23-dihydroxy-30-norolean-12, 20(29)-dien-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (4), and 3β, 23-dihydroxy-olean-12-en-28-oic acid 3-O-methyl β-D-glucopyranosyluronate-(1→3)-α-L-arabinopyranoside (5), respectively.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11515592</pmid><doi>10.1248/cpb.49.999</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification General pharmacology Holboellia fargesii Lardizabalaceae Medical sciences Medicine, Chinese Traditional Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Saponins - chemistry Saponins - isolation & purification Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Triterpenes - chemistry Triterpenes - isolation & purification triterpenoid saponin |
| title | Fargosides A-E, Triterpenoid Saponins from Holboellia fargesii |
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