VEGF-initiated Blood-Retinal Barrier Breakdown in Early Diabetes

The objectives of this study were to (1) determine whether endogenous vascular endothelial growth factor (VEGF) triggers diabetic blood-retinal barrier breakdown, and (2) identify the site as well as phenotype of the hyperpermeable diabetic retinal vessels. Retinal VEGF mRNA levels were quantified i...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2001-09, Vol.42 (10), p.2408-2413
Hauptverfasser:	Qaum, Tamim, Xu, Qingwen, Joussen, Antonia M, Clemens, Mark W, Qin, Wenying, Miyamoto, Kazuaki, Hassessian, Haroutioun, Wiegand, Stanley J, Rudge, John, Yancopoulos, George D, Adamis, Anthony P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Associated diseases and complications Biological and medical sciences Blood-Retinal Barrier - drug effects Capillary Permeability - drug effects Coloring Agents Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Diabetic Retinopathy - prevention & control Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - physiology Evans Blue Lymphokines - antagonists & inhibitors Lymphokines - physiology Male Medical sciences Rats Rats, Sprague-Dawley Retinal Vessels - drug effects Retinal Vessels - metabolism Retinal Vessels - pathology RNA, Messenger - analysis Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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