Effect of Dexamethasone Palmitate-Low Density Lipoprotein Complex on Cholesterol Ester Accumulation in Aorta of Atherogenic Model Mice
In order to confirm the efficacy of dexamethasone palmitate (DP)-low density lipoprotein (LDL) complex on experimental atherosclerosis in vivo, we examined whether DP-LDL complex could be effective for cholesterol ester accumulation in the aorta of atherogenic mice. Nonatherogenic and atherogenic mi...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2001, Vol.24(8), pp.925-929 |
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| creator | TAUCHI, Yoshihiko ZUSHIDA, Iichi CHONO, Sumio SATO, Juichi ITO, Keiji MORIMOTO, Kazuhiro |
| description | In order to confirm the efficacy of dexamethasone palmitate (DP)-low density lipoprotein (LDL) complex on experimental atherosclerosis in vivo, we examined whether DP-LDL complex could be effective for cholesterol ester accumulation in the aorta of atherogenic mice. Nonatherogenic and atherogenic mice were fed with normal and atherogenic diet for 14 weeks, respectively. Dexamethasone (DEX), lipid emulsion containing DP (DP-LE), or DP-LDL complex was intravenously injected once a week from 8 to 14 weeks. Cholesterol levels in serum and aorta in the atherogenic mice were significantly higher than those of nonatherogenic mice. Injection of DP-LDL complex significantly reduced cholesterol ester (CE) accumulation in the aorta of atherogenic mice. The reduction of CE accumulation in aorta treated with DP-LDL complexes was 10 and 100 times more potent than that with DP-LE and DEX, respectively. The radioactivity in the aorta of atherogenic mice treated with 3H-DP-LDL complex was significantly higher than that with 3H-DP-LE and 3H-DEX at 24 h after injection. Even 7 d after injection, a significant amount of radioactivity was present only in the aorta of atherogenic mice treated with DP-LDL complex. This result suggests that DP-LDL complex is selectively delivered to the atherogenic lesions in the aorta of atherogenic mice, and then DP released from the complex inhibits CE accumulation in the aortic intima. Therefore, DP-LDL complex may be a good drug-carrier in drug delivery system for atherosclerosis. |
| doi_str_mv | 10.1248/bpb.24.925 |
| format | Article |
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Nonatherogenic and atherogenic mice were fed with normal and atherogenic diet for 14 weeks, respectively. Dexamethasone (DEX), lipid emulsion containing DP (DP-LE), or DP-LDL complex was intravenously injected once a week from 8 to 14 weeks. Cholesterol levels in serum and aorta in the atherogenic mice were significantly higher than those of nonatherogenic mice. Injection of DP-LDL complex significantly reduced cholesterol ester (CE) accumulation in the aorta of atherogenic mice. The reduction of CE accumulation in aorta treated with DP-LDL complexes was 10 and 100 times more potent than that with DP-LE and DEX, respectively. The radioactivity in the aorta of atherogenic mice treated with 3H-DP-LDL complex was significantly higher than that with 3H-DP-LE and 3H-DEX at 24 h after injection. Even 7 d after injection, a significant amount of radioactivity was present only in the aorta of atherogenic mice treated with DP-LDL complex. This result suggests that DP-LDL complex is selectively delivered to the atherogenic lesions in the aorta of atherogenic mice, and then DP released from the complex inhibits CE accumulation in the aortic intima. Therefore, DP-LDL complex may be a good drug-carrier in drug delivery system for atherosclerosis.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.24.925</identifier><identifier>PMID: 11510487</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Aorta - metabolism ; Aorta - pathology ; Arteriosclerosis - metabolism ; Arteriosclerosis - prevention & control ; atherogenic mice ; atherosclerosis ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cholesterol - blood ; Cholesterol Esters - blood ; Cholesterol Esters - metabolism ; Dexamethasone - pharmacokinetics ; Dexamethasone - pharmacology ; dexamethasone palmitate ; Diet, Atherogenic ; drug delivery system ; drug-LDL complex ; Female ; General and cellular metabolism. Vitamins ; LDL ; Liver - metabolism ; Medical sciences ; Mice ; Mice, Inbred ICR ; Palmitates - pharmacokinetics ; Palmitates - pharmacology ; Pharmacology. Drug treatments</subject><ispartof>Biological and Pharmaceutical Bulletin, 2001, Vol.24(8), pp.925-929</ispartof><rights>2001 The Pharmaceutical Society of Japan</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c648t-3048b169dc114f94a6d4d2aa2c1272157ff61e0b9e2033f6431050570faa4c8c3</citedby><cites>FETCH-LOGICAL-c648t-3048b169dc114f94a6d4d2aa2c1272157ff61e0b9e2033f6431050570faa4c8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1106853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11510487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAUCHI, Yoshihiko</creatorcontrib><creatorcontrib>ZUSHIDA, Iichi</creatorcontrib><creatorcontrib>CHONO, Sumio</creatorcontrib><creatorcontrib>SATO, Juichi</creatorcontrib><creatorcontrib>ITO, Keiji</creatorcontrib><creatorcontrib>MORIMOTO, Kazuhiro</creatorcontrib><title>Effect of Dexamethasone Palmitate-Low Density Lipoprotein Complex on Cholesterol Ester Accumulation in Aorta of Atherogenic Model Mice</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>In order to confirm the efficacy of dexamethasone palmitate (DP)-low density lipoprotein (LDL) complex on experimental atherosclerosis in vivo, we examined whether DP-LDL complex could be effective for cholesterol ester accumulation in the aorta of atherogenic mice. Nonatherogenic and atherogenic mice were fed with normal and atherogenic diet for 14 weeks, respectively. Dexamethasone (DEX), lipid emulsion containing DP (DP-LE), or DP-LDL complex was intravenously injected once a week from 8 to 14 weeks. Cholesterol levels in serum and aorta in the atherogenic mice were significantly higher than those of nonatherogenic mice. Injection of DP-LDL complex significantly reduced cholesterol ester (CE) accumulation in the aorta of atherogenic mice. The reduction of CE accumulation in aorta treated with DP-LDL complexes was 10 and 100 times more potent than that with DP-LE and DEX, respectively. The radioactivity in the aorta of atherogenic mice treated with 3H-DP-LDL complex was significantly higher than that with 3H-DP-LE and 3H-DEX at 24 h after injection. Even 7 d after injection, a significant amount of radioactivity was present only in the aorta of atherogenic mice treated with DP-LDL complex. This result suggests that DP-LDL complex is selectively delivered to the atherogenic lesions in the aorta of atherogenic mice, and then DP released from the complex inhibits CE accumulation in the aortic intima. Therefore, DP-LDL complex may be a good drug-carrier in drug delivery system for atherosclerosis.</description><subject>Animals</subject><subject>Aorta - metabolism</subject><subject>Aorta - pathology</subject><subject>Arteriosclerosis - metabolism</subject><subject>Arteriosclerosis - prevention & control</subject><subject>atherogenic mice</subject><subject>atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cholesterol - blood</subject><subject>Cholesterol Esters - blood</subject><subject>Cholesterol Esters - metabolism</subject><subject>Dexamethasone - pharmacokinetics</subject><subject>Dexamethasone - pharmacology</subject><subject>dexamethasone palmitate</subject><subject>Diet, Atherogenic</subject><subject>drug delivery system</subject><subject>drug-LDL complex</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>LDL</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Palmitates - pharmacokinetics</subject><subject>Palmitates - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2O0zAUhSMEYjoDGx4AWQLNAinFN3biZIWqUn6kjmABa8txrqeunLjYjph5AZ4bVy0DYuNr6Xy651ydongBdAkVb9_2h35Z8WVX1Y-KBTAuyrqC-nGxoB20ZQN1e1FcxrinlApasafFBUANlLdiUfzaGIM6EW_Ie7xTI6adin5C8lW50SaVsNz6n1mbok33ZGsP_hB8QjuRtR8PDu-Iz9-ddxgTBu_I5jjJSut5nJ1KNssZXvmQ1NFllXYZu8XJanLjB3Tkxmp8VjwxykV8fp5XxfcPm2_rT-X2y8fP69W21A1vU8ly6B6abtAA3HRcNQMfKqUqDZXINwtjGkDad1hRxkzDGdCa1oIapbhuNbsqrk978xE_5hxZjjZqdE5N6OcoBQADwZoMvvoP3Ps5TDmbBM476GgjRKbenCgdfIwBjTwEO6pwL4HKYzcydyMrLnM3GX55Xjn3Iw5_0XMZGXh9BlTUypmgJm3jPxxt2ppl7N0J28ekbvFBVyFZ7fCPZXt6svODoncqSJzYb25nrbA</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>TAUCHI, Yoshihiko</creator><creator>ZUSHIDA, Iichi</creator><creator>CHONO, Sumio</creator><creator>SATO, Juichi</creator><creator>ITO, Keiji</creator><creator>MORIMOTO, Kazuhiro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Effect of Dexamethasone Palmitate-Low Density Lipoprotein Complex on Cholesterol Ester Accumulation in Aorta of Atherogenic Model Mice</title><author>TAUCHI, Yoshihiko ; ZUSHIDA, Iichi ; CHONO, Sumio ; SATO, Juichi ; ITO, Keiji ; MORIMOTO, Kazuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c648t-3048b169dc114f94a6d4d2aa2c1272157ff61e0b9e2033f6431050570faa4c8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Aorta - metabolism</topic><topic>Aorta - pathology</topic><topic>Arteriosclerosis - metabolism</topic><topic>Arteriosclerosis - prevention & control</topic><topic>atherogenic mice</topic><topic>atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cholesterol - blood</topic><topic>Cholesterol Esters - blood</topic><topic>Cholesterol Esters - metabolism</topic><topic>Dexamethasone - pharmacokinetics</topic><topic>Dexamethasone - pharmacology</topic><topic>dexamethasone palmitate</topic><topic>Diet, Atherogenic</topic><topic>drug delivery system</topic><topic>drug-LDL complex</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>LDL</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Palmitates - pharmacokinetics</topic><topic>Palmitates - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAUCHI, Yoshihiko</creatorcontrib><creatorcontrib>ZUSHIDA, Iichi</creatorcontrib><creatorcontrib>CHONO, Sumio</creatorcontrib><creatorcontrib>SATO, Juichi</creatorcontrib><creatorcontrib>ITO, Keiji</creatorcontrib><creatorcontrib>MORIMOTO, Kazuhiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAUCHI, Yoshihiko</au><au>ZUSHIDA, Iichi</au><au>CHONO, Sumio</au><au>SATO, Juichi</au><au>ITO, Keiji</au><au>MORIMOTO, Kazuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Dexamethasone Palmitate-Low Density Lipoprotein Complex on Cholesterol Ester Accumulation in Aorta of Atherogenic Model Mice</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>24</volume><issue>8</issue><spage>925</spage><epage>929</epage><pages>925-929</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>In order to confirm the efficacy of dexamethasone palmitate (DP)-low density lipoprotein (LDL) complex on experimental atherosclerosis in vivo, we examined whether DP-LDL complex could be effective for cholesterol ester accumulation in the aorta of atherogenic mice. Nonatherogenic and atherogenic mice were fed with normal and atherogenic diet for 14 weeks, respectively. Dexamethasone (DEX), lipid emulsion containing DP (DP-LE), or DP-LDL complex was intravenously injected once a week from 8 to 14 weeks. Cholesterol levels in serum and aorta in the atherogenic mice were significantly higher than those of nonatherogenic mice. Injection of DP-LDL complex significantly reduced cholesterol ester (CE) accumulation in the aorta of atherogenic mice. The reduction of CE accumulation in aorta treated with DP-LDL complexes was 10 and 100 times more potent than that with DP-LE and DEX, respectively. The radioactivity in the aorta of atherogenic mice treated with 3H-DP-LDL complex was significantly higher than that with 3H-DP-LE and 3H-DEX at 24 h after injection. Even 7 d after injection, a significant amount of radioactivity was present only in the aorta of atherogenic mice treated with DP-LDL complex. This result suggests that DP-LDL complex is selectively delivered to the atherogenic lesions in the aorta of atherogenic mice, and then DP released from the complex inhibits CE accumulation in the aortic intima. Therefore, DP-LDL complex may be a good drug-carrier in drug delivery system for atherosclerosis.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11510487</pmid><doi>10.1248/bpb.24.925</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Aorta - metabolism Aorta - pathology Arteriosclerosis - metabolism Arteriosclerosis - prevention & control atherogenic mice atherosclerosis Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cholesterol - blood Cholesterol Esters - blood Cholesterol Esters - metabolism Dexamethasone - pharmacokinetics Dexamethasone - pharmacology dexamethasone palmitate Diet, Atherogenic drug delivery system drug-LDL complex Female General and cellular metabolism. Vitamins LDL Liver - metabolism Medical sciences Mice Mice, Inbred ICR Palmitates - pharmacokinetics Palmitates - pharmacology Pharmacology. Drug treatments |
| title | Effect of Dexamethasone Palmitate-Low Density Lipoprotein Complex on Cholesterol Ester Accumulation in Aorta of Atherogenic Model Mice |
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