Ber‐EP4‐Positive Phenotype Differentiates Actinic Keratosis from Superficial Basal Cell Carcinoma
Background. Well‐defined histopathologic criteria exist to distinguish actinic keratosis (AK) from superficial basal cell carcinoma (BCC). A similar morphology of downwardly budding dysplastic keratinocytes may occur in both entities, creating potential for errors in diagnosis. A marker that could r...
Gespeichert in:
| Veröffentlicht in: | Dermatologic surgery 2000-05, Vol.26 (5), p.415-418 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 418 |
|---|---|
| container_issue | 5 |
| container_start_page | 415 |
| container_title | Dermatologic surgery |
| container_volume | 26 |
| creator | Tope, Whitney D. Nowfar‐Rad, Mehran Kist, David A. |
| description | Background. Well‐defined histopathologic criteria exist to distinguish actinic keratosis (AK) from superficial basal cell carcinoma (BCC). A similar morphology of downwardly budding dysplastic keratinocytes may occur in both entities, creating potential for errors in diagnosis. A marker that could reliably distinguish these two lesions would overcome this difficulty in diagnosis.
Objective. To investigate whether Ber‐EP4 staining is useful in distinguishing AK from superficial BCC, and to determine whether AK exhibits a cellular phenotype that is more consistent with BCC or squamous cell carcinoma (SCC).
Methods. We subjected tissue sections from superficial BCC, AK, and squamous intraepithelial neoplasia (SIN) demonstrating epidermal budding to immunohistochemical staining with monoclonal antibody Ber‐EP4.
Results. Abnormal keratinocytes in all specimens of superficial BCC (5 of 5) were Ber‐EP4 positive; all AK (10 of 10) and SIN (8 of 8) were Ber‐EP4 negative.
Conclusion. Ber‐EP4 staining reliably distinguishes AK from superficial BCC. The lack of Ber‐EP4 staining of AK supports the currently accepted pathogenetic dogma that SIN and SCC arise from AK, but BCC does not. |
| doi_str_mv | 10.1046/j.1524-4725.2000.99287.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71131605</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71131605</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3957-b5542941b9c402c91040bd9a09cb8eaebe04dac2cd9e078822a33348143f631c3</originalsourceid><addsrcrecordid>eNqNkMlOwzAQhi0EYn8FlAPiljBesviCBC2bQKIScLYcdyJcZSl2CvTGI_CMPAkurYAjl98j-RvP-CMkopBQENnxJKEpE7HIWZowAEikZEWevK2R7Z-L9VBDnsWQUrZFdryfAFAmOWySLQoFzRjLtgmeoft8_zgfiZCjztvevmA0esK26-dTjIa2qtBh21vdo49OTW9ba6IbdLoPtI8q1zXR_WyKrrLG6jo60z7kAOsQ2hnbdo3eIxuVrj3ur85d8nhx_jC4im_vLq8Hp7ex4TLN4zJNBZOCltIIYEaGv0I5lhqkKQvUWCKIsTbMjCVCXhSMac65KKjgVcap4bvkaPnu1HXPM_S9aqw3YRXdYjfzKqeU0wzSABZL0LjOe4eVmjrbaDdXFNRCsZqohUm1MKkWitW3YvUWWg9WM2Zlg-M_jUunAThcAdobXVdOt8b6X45LKSQP2MkSe7U1zv89Xw3vH79L_gUHK5kk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71131605</pqid></control><display><type>article</type><title>Ber‐EP4‐Positive Phenotype Differentiates Actinic Keratosis from Superficial Basal Cell Carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Tope, Whitney D. ; Nowfar‐Rad, Mehran ; Kist, David A.</creator><creatorcontrib>Tope, Whitney D. ; Nowfar‐Rad, Mehran ; Kist, David A.</creatorcontrib><description>Background. Well‐defined histopathologic criteria exist to distinguish actinic keratosis (AK) from superficial basal cell carcinoma (BCC). A similar morphology of downwardly budding dysplastic keratinocytes may occur in both entities, creating potential for errors in diagnosis. A marker that could reliably distinguish these two lesions would overcome this difficulty in diagnosis.
Objective. To investigate whether Ber‐EP4 staining is useful in distinguishing AK from superficial BCC, and to determine whether AK exhibits a cellular phenotype that is more consistent with BCC or squamous cell carcinoma (SCC).
Methods. We subjected tissue sections from superficial BCC, AK, and squamous intraepithelial neoplasia (SIN) demonstrating epidermal budding to immunohistochemical staining with monoclonal antibody Ber‐EP4.
Results. Abnormal keratinocytes in all specimens of superficial BCC (5 of 5) were Ber‐EP4 positive; all AK (10 of 10) and SIN (8 of 8) were Ber‐EP4 negative.
Conclusion. Ber‐EP4 staining reliably distinguishes AK from superficial BCC. The lack of Ber‐EP4 staining of AK supports the currently accepted pathogenetic dogma that SIN and SCC arise from AK, but BCC does not.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1046/j.1524-4725.2000.99287.x</identifier><identifier>PMID: 10816226</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>Antibodies, Monoclonal ; Antigens, Surface - analysis ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Basal Cell - diagnosis ; Carcinoma, Squamous Cell - diagnosis ; Dermatology ; Diagnosis, Differential ; Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue ; Humans ; Immunohistochemistry - methods ; Medical sciences ; Phenotype ; Precancerous Conditions - diagnosis ; Predictive Value of Tests ; Skin Neoplasms - diagnosis ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Dermatologic surgery, 2000-05, Vol.26 (5), p.415-418</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3957-b5542941b9c402c91040bd9a09cb8eaebe04dac2cd9e078822a33348143f631c3</citedby><cites>FETCH-LOGICAL-c3957-b5542941b9c402c91040bd9a09cb8eaebe04dac2cd9e078822a33348143f631c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1524-4725.2000.99287.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1524-4725.2000.99287.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1399493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10816226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tope, Whitney D.</creatorcontrib><creatorcontrib>Nowfar‐Rad, Mehran</creatorcontrib><creatorcontrib>Kist, David A.</creatorcontrib><title>Ber‐EP4‐Positive Phenotype Differentiates Actinic Keratosis from Superficial Basal Cell Carcinoma</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>Background. Well‐defined histopathologic criteria exist to distinguish actinic keratosis (AK) from superficial basal cell carcinoma (BCC). A similar morphology of downwardly budding dysplastic keratinocytes may occur in both entities, creating potential for errors in diagnosis. A marker that could reliably distinguish these two lesions would overcome this difficulty in diagnosis.
Objective. To investigate whether Ber‐EP4 staining is useful in distinguishing AK from superficial BCC, and to determine whether AK exhibits a cellular phenotype that is more consistent with BCC or squamous cell carcinoma (SCC).
Methods. We subjected tissue sections from superficial BCC, AK, and squamous intraepithelial neoplasia (SIN) demonstrating epidermal budding to immunohistochemical staining with monoclonal antibody Ber‐EP4.
Results. Abnormal keratinocytes in all specimens of superficial BCC (5 of 5) were Ber‐EP4 positive; all AK (10 of 10) and SIN (8 of 8) were Ber‐EP4 negative.
Conclusion. Ber‐EP4 staining reliably distinguishes AK from superficial BCC. The lack of Ber‐EP4 staining of AK supports the currently accepted pathogenetic dogma that SIN and SCC arise from AK, but BCC does not.</description><subject>Antibodies, Monoclonal</subject><subject>Antigens, Surface - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Basal Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Dermatology</subject><subject>Diagnosis, Differential</subject><subject>Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Medical sciences</subject><subject>Phenotype</subject><subject>Precancerous Conditions - diagnosis</subject><subject>Predictive Value of Tests</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EYn8FlAPiljBesviCBC2bQKIScLYcdyJcZSl2CvTGI_CMPAkurYAjl98j-RvP-CMkopBQENnxJKEpE7HIWZowAEikZEWevK2R7Z-L9VBDnsWQUrZFdryfAFAmOWySLQoFzRjLtgmeoft8_zgfiZCjztvevmA0esK26-dTjIa2qtBh21vdo49OTW9ba6IbdLoPtI8q1zXR_WyKrrLG6jo60z7kAOsQ2hnbdo3eIxuVrj3ur85d8nhx_jC4im_vLq8Hp7ex4TLN4zJNBZOCltIIYEaGv0I5lhqkKQvUWCKIsTbMjCVCXhSMac65KKjgVcap4bvkaPnu1HXPM_S9aqw3YRXdYjfzKqeU0wzSABZL0LjOe4eVmjrbaDdXFNRCsZqohUm1MKkWitW3YvUWWg9WM2Zlg-M_jUunAThcAdobXVdOt8b6X45LKSQP2MkSe7U1zv89Xw3vH79L_gUHK5kk</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Tope, Whitney D.</creator><creator>Nowfar‐Rad, Mehran</creator><creator>Kist, David A.</creator><general>Blackwell Science Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>Ber‐EP4‐Positive Phenotype Differentiates Actinic Keratosis from Superficial Basal Cell Carcinoma</title><author>Tope, Whitney D. ; Nowfar‐Rad, Mehran ; Kist, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3957-b5542941b9c402c91040bd9a09cb8eaebe04dac2cd9e078822a33348143f631c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibodies, Monoclonal</topic><topic>Antigens, Surface - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Basal Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Dermatology</topic><topic>Diagnosis, Differential</topic><topic>Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Medical sciences</topic><topic>Phenotype</topic><topic>Precancerous Conditions - diagnosis</topic><topic>Predictive Value of Tests</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tope, Whitney D.</creatorcontrib><creatorcontrib>Nowfar‐Rad, Mehran</creatorcontrib><creatorcontrib>Kist, David A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tope, Whitney D.</au><au>Nowfar‐Rad, Mehran</au><au>Kist, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ber‐EP4‐Positive Phenotype Differentiates Actinic Keratosis from Superficial Basal Cell Carcinoma</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2000-05</date><risdate>2000</risdate><volume>26</volume><issue>5</issue><spage>415</spage><epage>418</epage><pages>415-418</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>Background. Well‐defined histopathologic criteria exist to distinguish actinic keratosis (AK) from superficial basal cell carcinoma (BCC). A similar morphology of downwardly budding dysplastic keratinocytes may occur in both entities, creating potential for errors in diagnosis. A marker that could reliably distinguish these two lesions would overcome this difficulty in diagnosis.
Objective. To investigate whether Ber‐EP4 staining is useful in distinguishing AK from superficial BCC, and to determine whether AK exhibits a cellular phenotype that is more consistent with BCC or squamous cell carcinoma (SCC).
Methods. We subjected tissue sections from superficial BCC, AK, and squamous intraepithelial neoplasia (SIN) demonstrating epidermal budding to immunohistochemical staining with monoclonal antibody Ber‐EP4.
Results. Abnormal keratinocytes in all specimens of superficial BCC (5 of 5) were Ber‐EP4 positive; all AK (10 of 10) and SIN (8 of 8) were Ber‐EP4 negative.
Conclusion. Ber‐EP4 staining reliably distinguishes AK from superficial BCC. The lack of Ber‐EP4 staining of AK supports the currently accepted pathogenetic dogma that SIN and SCC arise from AK, but BCC does not.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>10816226</pmid><doi>10.1046/j.1524-4725.2000.99287.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1076-0512 |
| ispartof | Dermatologic surgery, 2000-05, Vol.26 (5), p.415-418 |
| issn | 1076-0512 1524-4725 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71131605 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Antibodies, Monoclonal Antigens, Surface - analysis Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Basal Cell - diagnosis Carcinoma, Squamous Cell - diagnosis Dermatology Diagnosis, Differential Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Humans Immunohistochemistry - methods Medical sciences Phenotype Precancerous Conditions - diagnosis Predictive Value of Tests Skin Neoplasms - diagnosis Tumors of the skin and soft tissue. Premalignant lesions |
| title | Ber‐EP4‐Positive Phenotype Differentiates Actinic Keratosis from Superficial Basal Cell Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T10%3A47%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ber%E2%80%90EP4%E2%80%90Positive%20Phenotype%20Differentiates%20Actinic%20Keratosis%20from%20Superficial%20Basal%20Cell%20Carcinoma&rft.jtitle=Dermatologic%20surgery&rft.au=Tope,%20Whitney%20D.&rft.date=2000-05&rft.volume=26&rft.issue=5&rft.spage=415&rft.epage=418&rft.pages=415-418&rft.issn=1076-0512&rft.eissn=1524-4725&rft_id=info:doi/10.1046/j.1524-4725.2000.99287.x&rft_dat=%3Cproquest_cross%3E71131605%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71131605&rft_id=info:pmid/10816226&rfr_iscdi=true |