Effect of flutamide-induced androgen-receptor blockade on adenylate cyclase activation through G-protein coupled receptors in rat prostate

The effect of the antiandrogen flutamide on the prostatic vasoactive intestinal peptide (VIP) receptor/effector system was studied in rats. Rats were s.c. injected with a daily dose of flutamide (15 mg/kg B.W.) or vehicle for 14 days. Drug treatment resulted in histological evidence of gland involut...

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Veröffentlicht in:	Cellular signalling 2000-05, Vol.12 (5), p.311-316
Hauptverfasser:	Montalvo, L., Carmena, M.J., Solano, R.M., Clemente, C., Román, I.D., Sánchez-Chapado, M., Prieto, Juan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adenylyl Cyclases - metabolism Androgen Antagonists - pharmacology Androgen Receptor Antagonists Animals Antiandrogen Apoptosis Apoptosis - drug effects Apoptosis - physiology Colforsin - pharmacology DNA Fragmentation Flutamide - pharmacology Forskolin GTP-Binding Proteins - metabolism Male Membrane Fluidity - drug effects Membrane Proteins - metabolism Orchiectomy Prostate - chemistry Prostate - enzymology Prostate - pathology Protein Binding - physiology Rat prostate Rats Rats, Wistar Receptors, Androgen - physiology Signal Transduction - drug effects Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology VIP
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