Disulfide Bonds Are Required for Folding and Secretion of Apolipoprotein B Regardless of Its Lipidation State

Apolipoprotein (apo) B-100, an essential protein for the assembly and secretion of very low density lipoproteins depends on lipid binding (lipidation) for its secretion. Seven of its 8 disulfides are clustered within the N-terminal 21%. The role of these disulfides in the secretion of lipidated or u...

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Veröffentlicht in:	The Journal of biological chemistry 2000-05, Vol.275 (21), p.16267-16274
Hauptverfasser:	Burch, William L., Herscovitz, Haya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins B - chemistry Apolipoproteins B - metabolism Disulfides - chemistry Dithiothreitol - pharmacology Lipids - chemistry Mice Protein Biosynthesis Protein Folding Tumor Cells, Cultured
Online-Zugang:	Volltext
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