Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota
The organic soluble extract from the leaves of Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the...
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| Veröffentlicht in: | Phytochemistry (Oxford) 2001-09, Vol.58 (1), p.153-157 |
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| container_title | Phytochemistry (Oxford) |
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| creator | Manfredi, Kirk P Vallurupalli, Vasanti Demidova, Maria Kindscher, Kelly Pannell, Lewis K |
| description | The organic soluble extract from the leaves of
Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete
1H NMR and
13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay.
The diprenylated bibenzyl
1 was isolated from
Glycyrrhiza lepidota. Its structural elucidation and biological activity against HIV-1 are reported. |
| doi_str_mv | 10.1016/S0031-9422(01)00177-7 |
| format | Article |
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Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete
1H NMR and
13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay.
The diprenylated bibenzyl
1 was isolated from
Glycyrrhiza lepidota. Its structural elucidation and biological activity against HIV-1 are reported.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/S0031-9422(01)00177-7</identifier><identifier>PMID: 11524125</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Anti-HIV Agents - chemistry ; Anti-HIV Agents - isolation & purification ; Anti-HIV Agents - pharmacology ; Bibenzyls - chemistry ; Bibenzyls - isolation & purification ; Bibenzyls - pharmacology ; Biological and medical sciences ; Carbon Isotopes ; Cell Line ; Chemical constitution ; diprenylated bibenzyl ; Fabaceae ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Glepidotin ; glepidotin A ; glepidotin B ; Glycyrrhiza - chemistry ; Glycyrrhiza lepidota ; HIV - drug effects ; HIV-1 ; Human immunodeficiency virus 1 ; Humans ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Leaves - chemistry ; Plant physiology and development ; Plant Stems - chemistry ; Plants, Medicinal - chemistry ; Prenylated ; Stilbenes</subject><ispartof>Phytochemistry (Oxford), 2001-09, Vol.58 (1), p.153-157</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-1f44c624f7ac350a572da9a90c9ed077ed6f074b076685af382cbe8cc5e48dae3</citedby><cites>FETCH-LOGICAL-c586t-1f44c624f7ac350a572da9a90c9ed077ed6f074b076685af382cbe8cc5e48dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031942201001777$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1125076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11524125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manfredi, Kirk P</creatorcontrib><creatorcontrib>Vallurupalli, Vasanti</creatorcontrib><creatorcontrib>Demidova, Maria</creatorcontrib><creatorcontrib>Kindscher, Kelly</creatorcontrib><creatorcontrib>Pannell, Lewis K</creatorcontrib><title>Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>The organic soluble extract from the leaves of
Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete
1H NMR and
13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay.
The diprenylated bibenzyl
1 was isolated from
Glycyrrhiza lepidota. Its structural elucidation and biological activity against HIV-1 are reported.</description><subject>Anti-HIV Agents - chemistry</subject><subject>Anti-HIV Agents - isolation & purification</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Bibenzyls - chemistry</subject><subject>Bibenzyls - isolation & purification</subject><subject>Bibenzyls - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbon Isotopes</subject><subject>Cell Line</subject><subject>Chemical constitution</subject><subject>diprenylated bibenzyl</subject><subject>Fabaceae</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Glepidotin</subject><subject>glepidotin A</subject><subject>glepidotin B</subject><subject>Glycyrrhiza - chemistry</subject><subject>Glycyrrhiza lepidota</subject><subject>HIV - drug effects</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Leaves - chemistry</subject><subject>Plant physiology and development</subject><subject>Plant Stems - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Prenylated</subject><subject>Stilbenes</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVoaTZpf0KCDyW0B6ejt30qJbTZhUAOeVyFLI2oitfaSN6A8-vjZJe2t8DAHOab10fICYVzClR9uwHgtG4FY1-AfgWgWtf6gCxoo3nNNcA7sviLHJKjUv4AgJRKfSCHlEomKJMLslyV1NsxpqFKobLDHGOsl6v7ysdNxmGai-irLnY4PE19FXJaV5f95Kacf8cnW_W4iT6N9iN5H2xf8NM-H5O7Xz9vL5b11fXl6uLHVe1ko8aaBiGcYiJo67gEKzXztrUtuBY9aI1eBdCiA61UI23gDXMdNs5JFI23yI_J2W7uJqeHLZbRrGNx2Pd2wLQtRlPKoRH8TZA2jKuWixmUO9DlVErGYDY5rm2eDAXz4tq8ujYvIg1Q8-ra6LnvdL9g263R_-vay52Bz3vAFmf7kO3gYvmPY3J-c8a-7zCctT1GzKa4iINDHzO60fgU37jkGSp4mpE</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Manfredi, Kirk P</creator><creator>Vallurupalli, Vasanti</creator><creator>Demidova, Maria</creator><creator>Kindscher, Kelly</creator><creator>Pannell, Lewis K</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota</title><author>Manfredi, Kirk P ; Vallurupalli, Vasanti ; Demidova, Maria ; Kindscher, Kelly ; Pannell, Lewis K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-1f44c624f7ac350a572da9a90c9ed077ed6f074b076685af382cbe8cc5e48dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anti-HIV Agents - chemistry</topic><topic>Anti-HIV Agents - isolation & purification</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Bibenzyls - chemistry</topic><topic>Bibenzyls - isolation & purification</topic><topic>Bibenzyls - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbon Isotopes</topic><topic>Cell Line</topic><topic>Chemical constitution</topic><topic>diprenylated bibenzyl</topic><topic>Fabaceae</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Glepidotin</topic><topic>glepidotin A</topic><topic>glepidotin B</topic><topic>Glycyrrhiza - chemistry</topic><topic>Glycyrrhiza lepidota</topic><topic>HIV - drug effects</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Leaves - chemistry</topic><topic>Plant physiology and development</topic><topic>Plant Stems - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Prenylated</topic><topic>Stilbenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manfredi, Kirk P</creatorcontrib><creatorcontrib>Vallurupalli, Vasanti</creatorcontrib><creatorcontrib>Demidova, Maria</creatorcontrib><creatorcontrib>Kindscher, Kelly</creatorcontrib><creatorcontrib>Pannell, Lewis K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manfredi, Kirk P</au><au>Vallurupalli, Vasanti</au><au>Demidova, Maria</au><au>Kindscher, Kelly</au><au>Pannell, Lewis K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>58</volume><issue>1</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>The organic soluble extract from the leaves of
Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete
1H NMR and
13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay.
The diprenylated bibenzyl
1 was isolated from
Glycyrrhiza lepidota. Its structural elucidation and biological activity against HIV-1 are reported.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>11524125</pmid><doi>10.1016/S0031-9422(01)00177-7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Anti-HIV Agents - chemistry Anti-HIV Agents - isolation & purification Anti-HIV Agents - pharmacology Bibenzyls - chemistry Bibenzyls - isolation & purification Bibenzyls - pharmacology Biological and medical sciences Carbon Isotopes Cell Line Chemical constitution diprenylated bibenzyl Fabaceae Fundamental and applied biological sciences. Psychology General pharmacology Glepidotin glepidotin A glepidotin B Glycyrrhiza - chemistry Glycyrrhiza lepidota HIV - drug effects HIV-1 Human immunodeficiency virus 1 Humans Magnetic Resonance Spectroscopy Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plant physiology and development Plant Stems - chemistry Plants, Medicinal - chemistry Prenylated Stilbenes |
| title | Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota |
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