Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential

We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutat...

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Veröffentlicht in:	Cancer letters 2000-07, Vol.155 (2), p.153-161
Hauptverfasser:	Sato, Norihiro, Mizumoto, Kazuhiro, Beppu, Kiichiro, Maehara, Naoki, Kusumoto, Masahiro, Nabae, Toshinaga, Morisaki, Takashi, Katano, Mitsuo, Tanaka, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiogenic factors Animal cells Animals Biological and medical sciences Biotechnology Blotting, Western Cachexia Cell Culture Techniques - methods Cell line Cell Movement Establishment of new cell lines, improvement of cultural methods, mass cultures Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Genes, ras - genetics Growth Substances - biosynthesis Growth Substances - genetics Humans Male Metastasis Methods. Procedures. Technologies Mice Mice, Nude Mutation Neoplasm Metastasis Neoplasm Transplantation Neovascularization, Pathologic Pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Telomerase - metabolism Time Factors Tumor Cells, Cultured
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