Endothelial perturbation in children and adolescents with type 1 diabetes : Association with markers of the inflammatory reaction
The progression of diabetic angiopathy is, in most cases, unpredictable. The aim of this study was to investigate early events that could influence the development of diabetic angiopathy. Circulating levels of von Willebrand factor (vWF) and tissue-plasminogen activator (tPA), defining endothelial p...
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| Veröffentlicht in: | Diabetes care 2001-09, Vol.24 (9), p.1674-1678 |
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| creator | ROMANO, Mario POMILIO, Mariapina VIGNERI, Sergio FALCO, Angela LELLI CHIESA, Pierluigi CHIARELLI, Francesco DAVI, Giovanni |
| description | The progression of diabetic angiopathy is, in most cases, unpredictable. The aim of this study was to investigate early events that could influence the development of diabetic angiopathy.
Circulating levels of von Willebrand factor (vWF) and tissue-plasminogen activator (tPA), defining endothelial perturbation, were measured in 40 young patients with type 1 diabetes. Patients were divided into two groups according to the duration of diabetes (group A, 1 year) and compared with a control group of age- and sex-matched healthy individuals. Prothrombin fragment 1 and 2 (F(1+2)), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) levels were also determined as markers of a prothrombotic state and inflammatory response. A total of 16 of the 20 children in group A were re-examined after 12 months.
Compared with either normal subjects or patients in group B, children in group A showed increased levels of vWF, tPA, F(1+2), TNF-alpha, and CRP. Significant direct correlations between TNF-alpha or CRP and either vWF, tPA, or F(1+2) were observed. Endothelial perturbation was shown in 70% of group A and 20% of group B. After 1 year, 16 of the 20 patients in group A showed a significant reduction in vWF, tPA, F(1+2), TNF-alpha, and CRP levels, whereas endothelial perturbation was reversed in 5 of these patients.
Endothelial perturbation represents an early and, in some cases, reversible event in the chronology of type 1 diabetes in children. A correlation might exist between the initial inflammatory reaction and the appearance of endothelial perturbation. |
| doi_str_mv | 10.2337/diacare.24.9.1674 |
| format | Article |
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Circulating levels of von Willebrand factor (vWF) and tissue-plasminogen activator (tPA), defining endothelial perturbation, were measured in 40 young patients with type 1 diabetes. Patients were divided into two groups according to the duration of diabetes (group A, <1 year; group B, >1 year) and compared with a control group of age- and sex-matched healthy individuals. Prothrombin fragment 1 and 2 (F(1+2)), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) levels were also determined as markers of a prothrombotic state and inflammatory response. A total of 16 of the 20 children in group A were re-examined after 12 months.
Compared with either normal subjects or patients in group B, children in group A showed increased levels of vWF, tPA, F(1+2), TNF-alpha, and CRP. Significant direct correlations between TNF-alpha or CRP and either vWF, tPA, or F(1+2) were observed. Endothelial perturbation was shown in 70% of group A and 20% of group B. After 1 year, 16 of the 20 patients in group A showed a significant reduction in vWF, tPA, F(1+2), TNF-alpha, and CRP levels, whereas endothelial perturbation was reversed in 5 of these patients.
Endothelial perturbation represents an early and, in some cases, reversible event in the chronology of type 1 diabetes in children. A correlation might exist between the initial inflammatory reaction and the appearance of endothelial perturbation.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.24.9.1674</identifier><identifier>PMID: 11522718</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adolescent ; Associated diseases and complications ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - analysis ; Child ; Children & youth ; Correlation analysis ; Development and progression ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic angiopathies ; Diabetic Angiopathies - physiopathology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium, Vascular - physiology ; Endothelium, Vascular - physiopathology ; Female ; Follow-Up Studies ; Glycated Hemoglobin A - analysis ; Humans ; Inflammation - blood ; Male ; Measurement ; Medical sciences ; Peptide Fragments - analysis ; Physiological aspects ; Protein Precursors - analysis ; Prothrombin - analysis ; Reference Values ; Studies ; Time Factors ; Tissue Plasminogen Activator - blood ; Tumor Necrosis Factor-alpha - analysis ; Type 1 diabetes ; Von Willebrand factor ; von Willebrand Factor - analysis</subject><ispartof>Diabetes care, 2001-09, Vol.24 (9), p.1674-1678</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Diabetes Association</rights><rights>Copyright American Diabetes Association Sep 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14069387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11522718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROMANO, Mario</creatorcontrib><creatorcontrib>POMILIO, Mariapina</creatorcontrib><creatorcontrib>VIGNERI, Sergio</creatorcontrib><creatorcontrib>FALCO, Angela</creatorcontrib><creatorcontrib>LELLI CHIESA, Pierluigi</creatorcontrib><creatorcontrib>CHIARELLI, Francesco</creatorcontrib><creatorcontrib>DAVI, Giovanni</creatorcontrib><title>Endothelial perturbation in children and adolescents with type 1 diabetes : Association with markers of the inflammatory reaction</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>The progression of diabetic angiopathy is, in most cases, unpredictable. The aim of this study was to investigate early events that could influence the development of diabetic angiopathy.
Circulating levels of von Willebrand factor (vWF) and tissue-plasminogen activator (tPA), defining endothelial perturbation, were measured in 40 young patients with type 1 diabetes. Patients were divided into two groups according to the duration of diabetes (group A, <1 year; group B, >1 year) and compared with a control group of age- and sex-matched healthy individuals. Prothrombin fragment 1 and 2 (F(1+2)), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) levels were also determined as markers of a prothrombotic state and inflammatory response. A total of 16 of the 20 children in group A were re-examined after 12 months.
Compared with either normal subjects or patients in group B, children in group A showed increased levels of vWF, tPA, F(1+2), TNF-alpha, and CRP. Significant direct correlations between TNF-alpha or CRP and either vWF, tPA, or F(1+2) were observed. Endothelial perturbation was shown in 70% of group A and 20% of group B. After 1 year, 16 of the 20 patients in group A showed a significant reduction in vWF, tPA, F(1+2), TNF-alpha, and CRP levels, whereas endothelial perturbation was reversed in 5 of these patients.
Endothelial perturbation represents an early and, in some cases, reversible event in the chronology of type 1 diabetes in children. A correlation might exist between the initial inflammatory reaction and the appearance of endothelial perturbation.</description><subject>Adolescent</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Child</subject><subject>Children & youth</subject><subject>Correlation analysis</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic angiopathies</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endothelium, Vascular - physiology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Peptide Fragments - analysis</subject><subject>Physiological aspects</subject><subject>Protein Precursors - analysis</subject><subject>Prothrombin - analysis</subject><subject>Reference Values</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Type 1 diabetes</subject><subject>Von Willebrand factor</subject><subject>von Willebrand Factor - analysis</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU2LFDEQhhtR3HH1B3iRIOjJHvPVk87ehmX9gAUvem6q05WZrOlkTNLIHP3nZp0RQZYcAlVPve9bSdO8ZHTNhVDvJwcGEq65XOs12yj5qFkxLbq262T_uFlRJnXbac0vmmc531FKpez7p80FYx3nivWr5tdNmGLZo3fgyQFTWdIIxcVAXCBm7_yUMBAIE4EpeswGQ8nkpyt7Uo4HJIzUECMWzOSKbHOOxp3G_yAzpO-YMomWVI8qaT3MM5SYjiQhmHvyefPEgs_44nxfNt8-3Hy9_tTefvn4-Xp72-6E0KWVqhcUq5UW1igrJmW1hA4FH9moGOspA5wsWEt5JznXtSX5uBEWJy6NFJfN25PuIcUfC-YyzK6u4z0EjEseqgbXaqMq-Po_8C4uKdRsA-eCdpQpXqF3J2gHHoe6WCwJzA4DJvAxoHW1vFV9J5nS9-btA3g9E87OPMS_OmdYxhmn4ZBcfcvj8PfjKvDmDEA24G2CYFz-x0m60aJX4jfhDKnt</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>ROMANO, Mario</creator><creator>POMILIO, Mariapina</creator><creator>VIGNERI, Sergio</creator><creator>FALCO, Angela</creator><creator>LELLI CHIESA, Pierluigi</creator><creator>CHIARELLI, Francesco</creator><creator>DAVI, Giovanni</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Endothelial perturbation in children and adolescents with type 1 diabetes : Association with markers of the inflammatory reaction</title><author>ROMANO, Mario ; POMILIO, Mariapina ; VIGNERI, Sergio ; FALCO, Angela ; LELLI CHIESA, Pierluigi ; CHIARELLI, Francesco ; DAVI, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g339t-47830eabe93fc7f3d7f94a5e32b1b711801aedfaff02542295e342b63fed24c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Child</topic><topic>Children & youth</topic><topic>Correlation analysis</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic angiopathies</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Endothelium, Vascular - physiology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical sciences</topic><topic>Peptide Fragments - analysis</topic><topic>Physiological aspects</topic><topic>Protein Precursors - analysis</topic><topic>Prothrombin - analysis</topic><topic>Reference Values</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Tissue Plasminogen Activator - blood</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Type 1 diabetes</topic><topic>Von Willebrand factor</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROMANO, Mario</creatorcontrib><creatorcontrib>POMILIO, Mariapina</creatorcontrib><creatorcontrib>VIGNERI, Sergio</creatorcontrib><creatorcontrib>FALCO, Angela</creatorcontrib><creatorcontrib>LELLI CHIESA, Pierluigi</creatorcontrib><creatorcontrib>CHIARELLI, Francesco</creatorcontrib><creatorcontrib>DAVI, Giovanni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROMANO, Mario</au><au>POMILIO, Mariapina</au><au>VIGNERI, Sergio</au><au>FALCO, Angela</au><au>LELLI CHIESA, Pierluigi</au><au>CHIARELLI, Francesco</au><au>DAVI, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial perturbation in children and adolescents with type 1 diabetes : Association with markers of the inflammatory reaction</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>24</volume><issue>9</issue><spage>1674</spage><epage>1678</epage><pages>1674-1678</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>The progression of diabetic angiopathy is, in most cases, unpredictable. The aim of this study was to investigate early events that could influence the development of diabetic angiopathy.
Circulating levels of von Willebrand factor (vWF) and tissue-plasminogen activator (tPA), defining endothelial perturbation, were measured in 40 young patients with type 1 diabetes. Patients were divided into two groups according to the duration of diabetes (group A, <1 year; group B, >1 year) and compared with a control group of age- and sex-matched healthy individuals. Prothrombin fragment 1 and 2 (F(1+2)), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) levels were also determined as markers of a prothrombotic state and inflammatory response. A total of 16 of the 20 children in group A were re-examined after 12 months.
Compared with either normal subjects or patients in group B, children in group A showed increased levels of vWF, tPA, F(1+2), TNF-alpha, and CRP. Significant direct correlations between TNF-alpha or CRP and either vWF, tPA, or F(1+2) were observed. Endothelial perturbation was shown in 70% of group A and 20% of group B. After 1 year, 16 of the 20 patients in group A showed a significant reduction in vWF, tPA, F(1+2), TNF-alpha, and CRP levels, whereas endothelial perturbation was reversed in 5 of these patients.
Endothelial perturbation represents an early and, in some cases, reversible event in the chronology of type 1 diabetes in children. A correlation might exist between the initial inflammatory reaction and the appearance of endothelial perturbation.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>11522718</pmid><doi>10.2337/diacare.24.9.1674</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Diabetes care, 2001-09, Vol.24 (9), p.1674-1678 |
| issn | 0149-5992 1935-5548 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Associated diseases and complications Biological and medical sciences Biomarkers - blood C-Reactive Protein - analysis Child Children & youth Correlation analysis Development and progression Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Diabetic angiopathies Diabetic Angiopathies - physiopathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - physiology Endothelium, Vascular - physiopathology Female Follow-Up Studies Glycated Hemoglobin A - analysis Humans Inflammation - blood Male Measurement Medical sciences Peptide Fragments - analysis Physiological aspects Protein Precursors - analysis Prothrombin - analysis Reference Values Studies Time Factors Tissue Plasminogen Activator - blood Tumor Necrosis Factor-alpha - analysis Type 1 diabetes Von Willebrand factor von Willebrand Factor - analysis |
| title | Endothelial perturbation in children and adolescents with type 1 diabetes : Association with markers of the inflammatory reaction |
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