Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53

The use of an Elb55k-deficient adenovirus, ONYX-015, to selectively target tumor cells containing a mutated p53 gene has produced promising results. However, recent reports have questioned the selectivity of this virus, showing that ONYX-015 can replicate in cells containing a wild-type p53 and that...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (10), p.2666-2672
Hauptverfasser:	DIX, B. R, O'CARROLL, S. J, MYERS, C. J, EDWARDS, S. J, BRAITHWAITE, A. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus Adenovirus E1B Proteins - metabolism Ageing, cell death Apoptosis Biological and medical sciences Cell Count Cell Cycle Cell Line Cell physiology E1B55k protein Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology p53 gene p53 protein Phenotype Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism
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