In vivo use of oligonucleotides to inhibit choroidal neovascularisation in the eye

Background We have previously demonstrated the in vivo uptake of oligonucleotides in the rat eye and have continued with experiments to look at the effectiveness of targeted oligonucleotide sequences. Vascular endothelial growth factor (VEGF) is correlated with new blood vessel formation and has bee...

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Veröffentlicht in:	The journal of gene medicine 2001-07, Vol.3 (4), p.373-383
Hauptverfasser:	Garrett, Kerryn L., Shen, Wei-Yong, Rakoczy, Piroska E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Choroid - blood supply choroidal neovascularisation Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - genetics eye Gene therapy Laser Coagulation Lymphokines - antagonists & inhibitors Lymphokines - genetics Neovascularization, Pathologic - prevention & control Oligodeoxyribonucleotides, Antisense - chemistry Oligodeoxyribonucleotides, Antisense - pharmacokinetics Oligodeoxyribonucleotides, Antisense - therapeutic use oligonucleotides Pigment Epithelium of Eye - blood supply Rats retinal pigment epithelial cells Reverse Transcriptase Polymerase Chain Reaction Structure-Activity Relationship Tissue Distribution vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors VEGF
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