Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles

The quaternisation of N-substituted benzimidazoles by heating with various alkyl, allyl, propargyl and benzyl chlorides and bromides leads to the formation of benzimidazolinium salts. The interaction of N-monosubstituted benzimidazoles with various salts (CuCl 2, ZnCl 2, CoCl 2, PdCl 2 and AgNO 3) y...

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Veröffentlicht in:	European journal of medicinal chemistry 2001-06, Vol.36 (6), p.507-515
Hauptverfasser:	Lukevics, Edmunds, Arsenyan, Pavel, Shestakova, Irina, Domracheva, Ilona, Nesterova, Alena, Pudova, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumour activity benzimidazole complexes benzimidazoles Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology benzimidazolinium salts Biological and medical sciences Cell Division - drug effects Cell Size - drug effects cytotoxic activity Drug Design Drug Evaluation, Preclinical General aspects Humans Magnetic Resonance Spectroscopy Medical sciences Mice Neoplasm Transplantation - pathology Pharmacology. Drug treatments Sarcoma - drug therapy Sarcoma - pathology Structure-Activity Relationship Tumor Cells, Cultured
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