Antioxidant Properties of Crocin from Gardenia jasminoides Ellis and Study of the Reactions of Crocin with Linoleic Acid and Crocin with Oxygen
Crocina water soluble carotenoidis found in the fruits of gardenia (Gardenia jasminoides Ellis) and in the stigmas of saffron (Crocus sativus Linne). For crocin purification, gardenia fruits are extracted with 50% acetone, followed by ether washing, ion exchange, and separation by preparative HPLC...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2000-05, Vol.48 (5), p.1455-1461 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Pham, Thanh Quan Cormier, François Farnworth, Edward Tong, Van Hang Van Calsteren, Marie-Rose |
| description | Crocina water soluble carotenoidis found in the fruits of gardenia (Gardenia jasminoides Ellis) and in the stigmas of saffron (Crocus sativus Linne). For crocin purification, gardenia fruits are extracted with 50% acetone, followed by ether washing, ion exchange, and separation by preparative HPLC. Purified crocin with purity of >99.6% has an antioxidative activity at concentrations up to 40 ppm. At 20 ppm the antioxidative activity of crocin is comparable to that of BHA. The antioxidant property of crocin as evaluated by the thiocyanate method was better than with the thiobarbituric acid method. The adduct between the linoleic acid radical and crocin was detected by LC-MS. When crocin reacted with oxygen in the presence of FeSO4, intermediates such as monohydroperoxides and dihydroperoxides of crocin were formed and detected by LC-MS. Keywords: Carotenoids; crocetin derivatives; antioxidant; thiocyanate method; TBA method; HPLC; MS |
| doi_str_mv | 10.1021/jf991263j |
| format | Article |
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For crocin purification, gardenia fruits are extracted with 50% acetone, followed by ether washing, ion exchange, and separation by preparative HPLC. Purified crocin with purity of >99.6% has an antioxidative activity at concentrations up to 40 ppm. At 20 ppm the antioxidative activity of crocin is comparable to that of BHA. The antioxidant property of crocin as evaluated by the thiocyanate method was better than with the thiobarbituric acid method. The adduct between the linoleic acid radical and crocin was detected by LC-MS. When crocin reacted with oxygen in the presence of FeSO4, intermediates such as monohydroperoxides and dihydroperoxides of crocin were formed and detected by LC-MS. Keywords: Carotenoids; crocetin derivatives; antioxidant; thiocyanate method; TBA method; HPLC; MS</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf991263j</identifier><identifier>PMID: 10820042</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Biological and medical sciences ; Carbohydrate Sequence ; Carotenoids - chemistry ; Carotenoids - isolation & purification ; Carotenoids - pharmacology ; Food additives ; Food industries ; Fundamental and applied biological sciences. Psychology ; General aspects ; General pharmacology ; Linoleic Acid - chemistry ; Medical sciences ; Oxygen - chemistry ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Agric. Food Chem</addtitle><description>Crocina water soluble carotenoidis found in the fruits of gardenia (Gardenia jasminoides Ellis) and in the stigmas of saffron (Crocus sativus Linne). For crocin purification, gardenia fruits are extracted with 50% acetone, followed by ether washing, ion exchange, and separation by preparative HPLC. Purified crocin with purity of >99.6% has an antioxidative activity at concentrations up to 40 ppm. At 20 ppm the antioxidative activity of crocin is comparable to that of BHA. The antioxidant property of crocin as evaluated by the thiocyanate method was better than with the thiobarbituric acid method. The adduct between the linoleic acid radical and crocin was detected by LC-MS. When crocin reacted with oxygen in the presence of FeSO4, intermediates such as monohydroperoxides and dihydroperoxides of crocin were formed and detected by LC-MS. Keywords: Carotenoids; crocetin derivatives; antioxidant; thiocyanate method; TBA method; HPLC; MS</description><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>Carotenoids - chemistry</subject><subject>Carotenoids - isolation & purification</subject><subject>Carotenoids - pharmacology</subject><subject>Food additives</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General pharmacology</subject><subject>Linoleic Acid - chemistry</subject><subject>Medical sciences</subject><subject>Oxygen - chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Psychology</topic><topic>General aspects</topic><topic>General pharmacology</topic><topic>Linoleic Acid - chemistry</topic><topic>Medical sciences</topic><topic>Oxygen - chemistry</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pham, Thanh Quan</creatorcontrib><creatorcontrib>Cormier, François</creatorcontrib><creatorcontrib>Farnworth, Edward</creatorcontrib><creatorcontrib>Tong, Van Hang</creatorcontrib><creatorcontrib>Van Calsteren, Marie-Rose</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pham, Thanh Quan</au><au>Cormier, François</au><au>Farnworth, Edward</au><au>Tong, Van Hang</au><au>Van Calsteren, Marie-Rose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Properties of Crocin from Gardenia jasminoides Ellis and Study of the Reactions of Crocin with Linoleic Acid and Crocin with Oxygen</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>48</volume><issue>5</issue><spage>1455</spage><epage>1461</epage><pages>1455-1461</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Crocina water soluble carotenoidis found in the fruits of gardenia (Gardenia jasminoides Ellis) and in the stigmas of saffron (Crocus sativus Linne). For crocin purification, gardenia fruits are extracted with 50% acetone, followed by ether washing, ion exchange, and separation by preparative HPLC. Purified crocin with purity of >99.6% has an antioxidative activity at concentrations up to 40 ppm. At 20 ppm the antioxidative activity of crocin is comparable to that of BHA. The antioxidant property of crocin as evaluated by the thiocyanate method was better than with the thiobarbituric acid method. The adduct between the linoleic acid radical and crocin was detected by LC-MS. When crocin reacted with oxygen in the presence of FeSO4, intermediates such as monohydroperoxides and dihydroperoxides of crocin were formed and detected by LC-MS. Keywords: Carotenoids; crocetin derivatives; antioxidant; thiocyanate method; TBA method; HPLC; MS</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>10820042</pmid><doi>10.1021/jf991263j</doi><tpages>7</tpages></addata></record> |
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| subjects | Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences Carbohydrate Sequence Carotenoids - chemistry Carotenoids - isolation & purification Carotenoids - pharmacology Food additives Food industries Fundamental and applied biological sciences. Psychology General aspects General pharmacology Linoleic Acid - chemistry Medical sciences Oxygen - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants - chemistry |
| title | Antioxidant Properties of Crocin from Gardenia jasminoides Ellis and Study of the Reactions of Crocin with Linoleic Acid and Crocin with Oxygen |
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