Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase

Endothelium-derived nitric oxide (NO) is produced by an oxidative reaction catalyzed by endothelial NO synthase (eNOS). NO plays a crucial role in controlling cell growth and apoptosis, as well as having well-characterized vasodilator and antithrombotic actions. More recently, endothelium-derived NO...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-05, Vol.101 (20), p.2345-2348
Hauptverfasser:	Lee, T C, Zhao, Y D, Courtman, D W, Stewart, D J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Valve - abnormalities Aortic Valve - enzymology Aortic Valve - pathology Embryo, Mammalian - metabolism Endothelium, Vascular - embryology Endothelium, Vascular - pathology Heart - embryology Heart Defects, Congenital - genetics Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout - genetics Nitric Oxide Synthase - deficiency Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Reference Values Tissue Distribution
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