Lactam Formation Increases Receptor Binding, Adenylyl Cyclase Stimulation and Bone Growth Stimulation by Human Parathyroid Hormone (hPTH)(1–28)NH2

Human parathyroid hormone (1–28)NH2 [hPTH(1–28)NH2] is the smallest of the PTH fragments that can fully stimulate adenylyl cyclase in ROS 17/2 rat osteoblast‐like osteosarcoma cells. This fragment has an IC50 of 110 nM for displacing 125I‐[Nle8,18, Tyr34]bovine PTH(1–34)NH2 from HKRK B7 porcine kidn...

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Veröffentlicht in:	Journal of bone and mineral research 2000-05, Vol.15 (5), p.964-970
Hauptverfasser:	Whitfield, J. F., Morley, P., Willick, G. E., Isaacs, R. J., MacLean, S., Ross, V., Barbier, J.‐R., Divieti, P., Bringhurst, F. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals bone Bone Development - drug effects Cell Line Enzyme Activation Humans Lactams - metabolism osteoporosis parathyroid hormone Peptide Fragments - pharmacology Protein Binding Rats Rats, Sprague-Dawley receptors Receptors, Parathyroid Hormone - metabolism Swine Teriparatide - analogs & derivatives Teriparatide - pharmacology trabecular
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