Lipid phase fatty acid flip-flop, is it fast enough for cellular transport?
The mechanism by which fatty acids are transported across cell membranes is controversial. The essence of the controversy is whether transport requires membrane protein mediation or whether the membrane's lipid phase provides a pathway so rapid that a protein is not needed. This review focuses...
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| Veröffentlicht in: | The Journal of membrane biology 2000-05, Vol.175 (2), p.79-86 |
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| container_title | The Journal of membrane biology |
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| creator | Kleinfeld, A M |
| description | The mechanism by which fatty acids are transported across cell membranes is controversial. The essence of the controversy is whether transport requires membrane protein mediation or whether the membrane's lipid phase provides a pathway so rapid that a protein is not needed. This review focuses on the mechanisms of fatty acid transport across lipid bilayer membranes. These results for lipid membranes are used to help evaluate transport across cell membranes. Within the context of this analysis, a lipid phase mediated process is consistent with results for the transport of fatty acids across erythrocytes but provides a less adequate explanation for fatty acid transport across more complex cells. |
| doi_str_mv | 10.1007/s002320001056 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-2631 |
| ispartof | The Journal of membrane biology, 2000-05, Vol.175 (2), p.79-86 |
| issn | 0022-2631 1432-1424 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Animals Biological Transport Cell Membrane - metabolism Erythrocyte Membrane - metabolism Fatty Acids - metabolism Membrane Lipids - metabolism |
| title | Lipid phase fatty acid flip-flop, is it fast enough for cellular transport? |
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