Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma
The c-Kit protein, a receptor type tyrosine kinase that plays an important role in the development of hematopoietic cells, melanocytes, and germ cells, is expressed in mastocytosis, gastrointestinal stromal cell tumors (GISTs), germ cell tumors, and several other tumors. Gain-of-function mutations i...
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| Veröffentlicht in: | Cancer letters 2000-06, Vol.154 (1), p.107-111 |
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| creator | Jeng, Yung-Ming Lin, Chiao-Ying Hsu, Hey-Chi |
| description | The c-Kit protein, a receptor type tyrosine kinase that plays an important role in the development of hematopoietic cells, melanocytes, and germ cells, is expressed in mastocytosis, gastrointestinal stromal cell tumors (GISTs), germ cell tumors, and several other tumors. Gain-of-function mutations in exon 11 and exon 17 have been shown as a mechanism of c-kit activation in some tumors. To study the role of c-kit in salivary gland carcinomas, we analyzed the c-kit protein expression in 79 carcinomas of major and minor salivary glands by immunohistochemistry. Although varying in intensity of staining, c-kit expression was identified very often in adenoid cystic carcinomas (20/25), lymphoepithelioma-like carcinomas (6/6) and myoepithelial carcinomas (2/2), but not in other types of salivary gland carcinoma (0/46),
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| doi_str_mv | 10.1016/S0304-3835(00)00387-6 |
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P<0.00001. By DNA sequencing, genetic alteration of
c-kit juxtamembrane domain (exon 11) and tyrosine kinase domain (exon 17) was not found in all the three types of salivary carcinoma that had c-kit protein expression. In conclusion, c-kit protein overexpression is involved in the pathogenesis of certain types of salivary gland carcinoma, but mutation of the gene is not the mechanism of c-kit activation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(00)00387-6</identifier><identifier>PMID: 10799746</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adenoid cystic carcinoma ; Biological and medical sciences ; c-kit ; c-kit gene ; Carcinoma, Acinar Cell - genetics ; Carcinoma, Acinar Cell - metabolism ; Carcinoma, Adenoid Cystic - genetics ; Carcinoma, Adenoid Cystic - metabolism ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Exons ; Humans ; Immunohistochemistry ; Medical sciences ; Mutation ; Myoepithelioma - genetics ; Myoepithelioma - metabolism ; Otorhinolaryngology. Stomatology ; Proto-Oncogene Proteins c-kit - biosynthesis ; Proto-Oncogene Proteins c-kit - genetics ; Salivary gland neoplasms ; Salivary Gland Neoplasms - genetics ; Salivary Gland Neoplasms - metabolism ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Cancer letters, 2000-06, Vol.154 (1), p.107-111</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-6d3ed2756c879779f63221b79456b242afb8dab2677bd8be91ec4f7f3109686b3</citedby><cites>FETCH-LOGICAL-c421t-6d3ed2756c879779f63221b79456b242afb8dab2677bd8be91ec4f7f3109686b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383500003876$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1405052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10799746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeng, Yung-Ming</creatorcontrib><creatorcontrib>Lin, Chiao-Ying</creatorcontrib><creatorcontrib>Hsu, Hey-Chi</creatorcontrib><title>Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The c-Kit protein, a receptor type tyrosine kinase that plays an important role in the development of hematopoietic cells, melanocytes, and germ cells, is expressed in mastocytosis, gastrointestinal stromal cell tumors (GISTs), germ cell tumors, and several other tumors. Gain-of-function mutations in exon 11 and exon 17 have been shown as a mechanism of c-kit activation in some tumors. To study the role of c-kit in salivary gland carcinomas, we analyzed the c-kit protein expression in 79 carcinomas of major and minor salivary glands by immunohistochemistry. Although varying in intensity of staining, c-kit expression was identified very often in adenoid cystic carcinomas (20/25), lymphoepithelioma-like carcinomas (6/6) and myoepithelial carcinomas (2/2), but not in other types of salivary gland carcinoma (0/46),
P<0.00001. By DNA sequencing, genetic alteration of
c-kit juxtamembrane domain (exon 11) and tyrosine kinase domain (exon 17) was not found in all the three types of salivary carcinoma that had c-kit protein expression. In conclusion, c-kit protein overexpression is involved in the pathogenesis of certain types of salivary gland carcinoma, but mutation of the gene is not the mechanism of c-kit activation.</description><subject>Adenoid cystic carcinoma</subject><subject>Biological and medical sciences</subject><subject>c-kit</subject><subject>c-kit gene</subject><subject>Carcinoma, Acinar Cell - genetics</subject><subject>Carcinoma, Acinar Cell - metabolism</subject><subject>Carcinoma, Adenoid Cystic - genetics</subject><subject>Carcinoma, Adenoid Cystic - metabolism</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Exons</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Myoepithelioma - genetics</subject><subject>Myoepithelioma - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Proto-Oncogene Proteins c-kit - biosynthesis</subject><subject>Proto-Oncogene Proteins c-kit - genetics</subject><subject>Salivary gland neoplasms</subject><subject>Salivary Gland Neoplasms - genetics</subject><subject>Salivary Gland Neoplasms - metabolism</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1ERZfCRwD5gBAcAmPH_3KqUFWgUqUegLNlOxNqyCaLx1votyfbXUFvPc3Bv-d58x5jLwS8EyDM-y_Qgmpa1-o3AG8BWmcb84ithLOysZ2Dx2z1DzlmT4l-AIBWVj9hxwJs11llVsyf_9kUJMrzxOeB12vkqfmZK9-UuWKeeCYeiOaUQ8We_871micsNSxPtI31doO0E1IY800ot_z7GKaep1BSnuZ1eMaOhjASPj_ME_bt4_nXs8_N5dWni7MPl01SUtTG9C320mqTnO2s7QbTSimi7ZQ2USoZhuj6EKWxNvYuYicwqcEOrYDOOBPbE_Z6_-_i-9cWqfp1poTj4gbnLXkrhNRK2gdBYbVyxpgF1HswlZmo4OA3Ja-XE70Av6vA31Xgd_l6AH9Xgd_pXh4WbOMa-3uqfeYL8OoABEphHEqYUqb_nAINWi7Y6R7DJbabjMVTyjgl7HPBVH0_5wec_AXPkKLR</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Jeng, Yung-Ming</creator><creator>Lin, Chiao-Ying</creator><creator>Hsu, Hey-Chi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma</title><author>Jeng, Yung-Ming ; Lin, Chiao-Ying ; Hsu, Hey-Chi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6d3ed2756c879779f63221b79456b242afb8dab2677bd8be91ec4f7f3109686b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenoid cystic carcinoma</topic><topic>Biological and medical sciences</topic><topic>c-kit</topic><topic>c-kit gene</topic><topic>Carcinoma, Acinar Cell - genetics</topic><topic>Carcinoma, Acinar Cell - metabolism</topic><topic>Carcinoma, Adenoid Cystic - genetics</topic><topic>Carcinoma, Adenoid Cystic - metabolism</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Exons</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Myoepithelioma - genetics</topic><topic>Myoepithelioma - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Proto-Oncogene Proteins c-kit - biosynthesis</topic><topic>Proto-Oncogene Proteins c-kit - genetics</topic><topic>Salivary gland neoplasms</topic><topic>Salivary Gland Neoplasms - genetics</topic><topic>Salivary Gland Neoplasms - metabolism</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeng, Yung-Ming</creatorcontrib><creatorcontrib>Lin, Chiao-Ying</creatorcontrib><creatorcontrib>Hsu, Hey-Chi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeng, Yung-Ming</au><au>Lin, Chiao-Ying</au><au>Hsu, Hey-Chi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>154</volume><issue>1</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The c-Kit protein, a receptor type tyrosine kinase that plays an important role in the development of hematopoietic cells, melanocytes, and germ cells, is expressed in mastocytosis, gastrointestinal stromal cell tumors (GISTs), germ cell tumors, and several other tumors. Gain-of-function mutations in exon 11 and exon 17 have been shown as a mechanism of c-kit activation in some tumors. To study the role of c-kit in salivary gland carcinomas, we analyzed the c-kit protein expression in 79 carcinomas of major and minor salivary glands by immunohistochemistry. Although varying in intensity of staining, c-kit expression was identified very often in adenoid cystic carcinomas (20/25), lymphoepithelioma-like carcinomas (6/6) and myoepithelial carcinomas (2/2), but not in other types of salivary gland carcinoma (0/46),
P<0.00001. By DNA sequencing, genetic alteration of
c-kit juxtamembrane domain (exon 11) and tyrosine kinase domain (exon 17) was not found in all the three types of salivary carcinoma that had c-kit protein expression. In conclusion, c-kit protein overexpression is involved in the pathogenesis of certain types of salivary gland carcinoma, but mutation of the gene is not the mechanism of c-kit activation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10799746</pmid><doi>10.1016/S0304-3835(00)00387-6</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenoid cystic carcinoma Biological and medical sciences c-kit c-kit gene Carcinoma, Acinar Cell - genetics Carcinoma, Acinar Cell - metabolism Carcinoma, Adenoid Cystic - genetics Carcinoma, Adenoid Cystic - metabolism Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Exons Humans Immunohistochemistry Medical sciences Mutation Myoepithelioma - genetics Myoepithelioma - metabolism Otorhinolaryngology. Stomatology Proto-Oncogene Proteins c-kit - biosynthesis Proto-Oncogene Proteins c-kit - genetics Salivary gland neoplasms Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma |
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