A Single Postoperative Application of Nitroglycerin Ointment Does Not Increase Survival of Cutaneous Flaps and Grafts
BACKGROUND. Nitroglycerin is a vasodilator that has been reported to improve cutaneous flap and graft survival. It has not been tested in controlled studies. OBJECTIVE. We designed our study to test the effectiveness of a single postoperative application of nitroglycerin on flap and graft survival....
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| Veröffentlicht in: | Dermatologic surgery 2000-05, Vol.26 (5), p.425-427 |
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| container_end_page | 427 |
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| container_issue | 5 |
| container_start_page | 425 |
| container_title | Dermatologic surgery |
| container_volume | 26 |
| creator | Dunn, Cary L. Brodland, David G. Griego, Robert D. Huether, Michael J. Fazio, Michael J. Zitelli, John A. |
| description | BACKGROUND.
Nitroglycerin is a vasodilator that has been reported to improve cutaneous flap and graft survival. It has not been tested in controlled studies.
OBJECTIVE.
We designed our study to test the effectiveness of a single postoperative application of nitroglycerin on flap and graft survival.
METHODS.
Eighty‐eight surgical repairs received topical nitroglycerin and 85 received control ointment (polysporin). Treatment sites were evaluated on postoperative day 7 and assigned a percentage of surface area survival.
RESULTS.
There was no significant difference in the complication rate of flaps and grafts treated with nitroglycerin (12.5%) compared with those treated with control ointment (8.4%) (P = .244). Subset analysis of flaps as a group and grafts as a group were not meaningful because the complication rates were so low.
CONCLUSION. There is no survival increase of flaps and grafts treated with a single application of nitroglycerin ointment. |
| doi_str_mv | 10.1046/j.1524-4725.2000.99307.x |
| format | Article |
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Nitroglycerin is a vasodilator that has been reported to improve cutaneous flap and graft survival. It has not been tested in controlled studies.
OBJECTIVE.
We designed our study to test the effectiveness of a single postoperative application of nitroglycerin on flap and graft survival.
METHODS.
Eighty‐eight surgical repairs received topical nitroglycerin and 85 received control ointment (polysporin). Treatment sites were evaluated on postoperative day 7 and assigned a percentage of surface area survival.
RESULTS.
There was no significant difference in the complication rate of flaps and grafts treated with nitroglycerin (12.5%) compared with those treated with control ointment (8.4%) (P = .244). Subset analysis of flaps as a group and grafts as a group were not meaningful because the complication rates were so low.
CONCLUSION. There is no survival increase of flaps and grafts treated with a single application of nitroglycerin ointment.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1046/j.1524-4725.2000.99307.x</identifier><identifier>PMID: 10816228</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>Administration, Cutaneous ; Disease-Free Survival ; Double-Blind Method ; Graft Survival - drug effects ; Humans ; Mohs Surgery ; Nitroglycerin - administration & dosage ; Ointments ; Postoperative Care ; Skin Neoplasms - surgery ; Skin Transplantation ; Surgical Flaps ; Treatment Outcome ; Vasodilator Agents - administration & dosage ; Wound Healing - drug effects</subject><ispartof>Dermatologic surgery, 2000-05, Vol.26 (5), p.425-427</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3667-6081f3786cbc266973703ce3b666b69a87d0dd04b0747cd2ca6c98d1556d58513</citedby><cites>FETCH-LOGICAL-c3667-6081f3786cbc266973703ce3b666b69a87d0dd04b0747cd2ca6c98d1556d58513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1524-4725.2000.99307.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1524-4725.2000.99307.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10816228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dunn, Cary L.</creatorcontrib><creatorcontrib>Brodland, David G.</creatorcontrib><creatorcontrib>Griego, Robert D.</creatorcontrib><creatorcontrib>Huether, Michael J.</creatorcontrib><creatorcontrib>Fazio, Michael J.</creatorcontrib><creatorcontrib>Zitelli, John A.</creatorcontrib><title>A Single Postoperative Application of Nitroglycerin Ointment Does Not Increase Survival of Cutaneous Flaps and Grafts</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>BACKGROUND.
Nitroglycerin is a vasodilator that has been reported to improve cutaneous flap and graft survival. It has not been tested in controlled studies.
OBJECTIVE.
We designed our study to test the effectiveness of a single postoperative application of nitroglycerin on flap and graft survival.
METHODS.
Eighty‐eight surgical repairs received topical nitroglycerin and 85 received control ointment (polysporin). Treatment sites were evaluated on postoperative day 7 and assigned a percentage of surface area survival.
RESULTS.
There was no significant difference in the complication rate of flaps and grafts treated with nitroglycerin (12.5%) compared with those treated with control ointment (8.4%) (P = .244). Subset analysis of flaps as a group and grafts as a group were not meaningful because the complication rates were so low.
CONCLUSION. There is no survival increase of flaps and grafts treated with a single application of nitroglycerin ointment.</description><subject>Administration, Cutaneous</subject><subject>Disease-Free Survival</subject><subject>Double-Blind Method</subject><subject>Graft Survival - drug effects</subject><subject>Humans</subject><subject>Mohs Surgery</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Ointments</subject><subject>Postoperative Care</subject><subject>Skin Neoplasms - surgery</subject><subject>Skin Transplantation</subject><subject>Surgical Flaps</subject><subject>Treatment Outcome</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Wound Healing - drug effects</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1q4zAUhcXQYfo3rzBo1Z3dK9mW7E0hpNMfKOlA2rWQZbkoKJYryWnz9mPHpXTZlQ7oO_dePoQwgZRAzi43KSlonuScFikFgLSqMuDp-w908vlxNGbgLIGC0GN0GsIGgNCR-4WOCZSEUVqeoGGB16Z7sRr_cyG6XnsZzU7jRd9bo8bsOuxavDLRuxe7V9qbDj-aLm51F_G10wGvXMT3nfJaBo3Xg9-ZnbRTaTlE2Wk3BHxjZR-w7Bp862Ubwzn62Uob9O-P9ww93_x9Wt4lD4-398vFQ6IyxnjCxjPbjJdM1YoyVvGMQ6Z0VjPGalbJkjfQNJDXwHOuGqokU1XZkKJgTVEWJDtDF_Pc3rvXQYcotiYobe18l-CEUMIqGMFyBpV3IXjdit6brfR7QUBMysVGTGbFZFZMysVBuXgfq38-dgz1VjdfirPjEbiagTdj9f7bg8X1-vkQs_-87ZBW</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Dunn, Cary L.</creator><creator>Brodland, David G.</creator><creator>Griego, Robert D.</creator><creator>Huether, Michael J.</creator><creator>Fazio, Michael J.</creator><creator>Zitelli, John A.</creator><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>A Single Postoperative Application of Nitroglycerin Ointment Does Not Increase Survival of Cutaneous Flaps and Grafts</title><author>Dunn, Cary L. ; Brodland, David G. ; Griego, Robert D. ; Huether, Michael J. ; Fazio, Michael J. ; Zitelli, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3667-6081f3786cbc266973703ce3b666b69a87d0dd04b0747cd2ca6c98d1556d58513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Cutaneous</topic><topic>Disease-Free Survival</topic><topic>Double-Blind Method</topic><topic>Graft Survival - drug effects</topic><topic>Humans</topic><topic>Mohs Surgery</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Ointments</topic><topic>Postoperative Care</topic><topic>Skin Neoplasms - surgery</topic><topic>Skin Transplantation</topic><topic>Surgical Flaps</topic><topic>Treatment Outcome</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dunn, Cary L.</creatorcontrib><creatorcontrib>Brodland, David G.</creatorcontrib><creatorcontrib>Griego, Robert D.</creatorcontrib><creatorcontrib>Huether, Michael J.</creatorcontrib><creatorcontrib>Fazio, Michael J.</creatorcontrib><creatorcontrib>Zitelli, John A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dunn, Cary L.</au><au>Brodland, David G.</au><au>Griego, Robert D.</au><au>Huether, Michael J.</au><au>Fazio, Michael J.</au><au>Zitelli, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Single Postoperative Application of Nitroglycerin Ointment Does Not Increase Survival of Cutaneous Flaps and Grafts</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2000-05</date><risdate>2000</risdate><volume>26</volume><issue>5</issue><spage>425</spage><epage>427</epage><pages>425-427</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>BACKGROUND.
Nitroglycerin is a vasodilator that has been reported to improve cutaneous flap and graft survival. It has not been tested in controlled studies.
OBJECTIVE.
We designed our study to test the effectiveness of a single postoperative application of nitroglycerin on flap and graft survival.
METHODS.
Eighty‐eight surgical repairs received topical nitroglycerin and 85 received control ointment (polysporin). Treatment sites were evaluated on postoperative day 7 and assigned a percentage of surface area survival.
RESULTS.
There was no significant difference in the complication rate of flaps and grafts treated with nitroglycerin (12.5%) compared with those treated with control ointment (8.4%) (P = .244). Subset analysis of flaps as a group and grafts as a group were not meaningful because the complication rates were so low.
CONCLUSION. There is no survival increase of flaps and grafts treated with a single application of nitroglycerin ointment.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>10816228</pmid><doi>10.1046/j.1524-4725.2000.99307.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Dermatologic surgery, 2000-05, Vol.26 (5), p.425-427 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Access via Wiley Online Library |
| subjects | Administration, Cutaneous Disease-Free Survival Double-Blind Method Graft Survival - drug effects Humans Mohs Surgery Nitroglycerin - administration & dosage Ointments Postoperative Care Skin Neoplasms - surgery Skin Transplantation Surgical Flaps Treatment Outcome Vasodilator Agents - administration & dosage Wound Healing - drug effects |
| title | A Single Postoperative Application of Nitroglycerin Ointment Does Not Increase Survival of Cutaneous Flaps and Grafts |
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