Structure-Activity Relationship Studies on Potential Non-Nucleoside DABO-Like Inhibitors of HIV-1 Reverse Transcriptase

Using 2,6-dichloro-4-aminopyrimidine, a number of uracil and cytosine derivatives with both arylthio and alkoxy moieties were prepared. These novel pyrimidines share chemical similarities with DABOs and HEPTs, two classes of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcrip...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 2000-03, Vol.11 (2), p.117-133
Hauptverfasser:	Costi, Roberta, Di Santo, Roberto, Artico, Marino, Massa, Silvio, Lavecchia, Antonio, Marceddu, Tiziana, Sanna, Laura, La Colla, Paolo, Marongiu, Maria Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	2,6-Dichloro-4-aminopyrimidine AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiviral activity Antiviral agents Biological and medical sciences Cytosine Cytotoxicity Drug Evaluation, Preclinical - methods HIV Human immunodeficiency virus Human immunodeficiency virus 1 Humans Medical sciences Microbial Sensitivity Tests - methods MT-4 cells Nucleosides - chemistry Oxidation Pharmacology. Drug treatments Pyrimidines Pyrimidinones - chemistry Pyrimidinones - pharmacology Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology RNA-directed DNA polymerase Structure-Activity Relationship Sulfides - chemistry Sulfides - pharmacology Uracil Zidovudine
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