The effect of high-dose pentaerythritol tetranitrate on the development of nitrate tolerance in rabbits

Experimental studies with therapeutic doses of pentaerythritol tetranitrate (PETN) have shown unexpected actions such as a lack of nitrate tolerance and vasoprotective effects in atherosclerosis. We investigated the effect of a 3-week treatment with low- (6 mg kg(-1) day(-1), n=10) and high-dose (10...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2001-09, Vol.364 (3), p.269-275
Hauptverfasser:	Müllenheim, J, Müller, S, Laber, U, Thämer, V, Meyer, W, Bassenge, E, Fink, B, Kojda, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Tolerance Hemodynamics - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Nitrates - pharmacology Pentaerythritol Tetranitrate - pharmacology Rabbits Reactive Oxygen Species - metabolism Vasodilator Agents - pharmacology
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