Detection of non-linearity in the EEG of schizophrenic patients

The aim of this study is to detect non-linearity in the EEG of schizophrenia with a modified method of surrogate data. We also want to identify if dimension complexity (correlation dimension using spatial embedding) could be used as a discriminating statistic to demonstrate non-linearity in the EEG....

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Veröffentlicht in:Clinical neurophysiology 2001-07, Vol.112 (7), p.1288-1294
Hauptverfasser: LEE, Ying-Jie, ZHU, Yi-Sheng, XU, Yu-Hong, SHEN, Min-Fen, ZHANG, Hong-Xuan, THAKOR, N. V
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container_end_page 1294
container_issue 7
container_start_page 1288
container_title Clinical neurophysiology
container_volume 112
creator LEE, Ying-Jie
ZHU, Yi-Sheng
XU, Yu-Hong
SHEN, Min-Fen
ZHANG, Hong-Xuan
THAKOR, N. V
description The aim of this study is to detect non-linearity in the EEG of schizophrenia with a modified method of surrogate data. We also want to identify if dimension complexity (correlation dimension using spatial embedding) could be used as a discriminating statistic to demonstrate non-linearity in the EEG. The difference between the attractor dimension of healthy subjects and schizophrenic subjects is expected to be interpreted as reflecting some mechanisms underlying brain wave by views of non-linear dynamics analysis may reflect mechanistic differences. EEGs were recorded with 14 electrodes in 18 healthy male subjects (average age: 26.3; range: 20--35) and 18 male schizophrenic patients (average age: 30.6; range: 24--40) during a resting eye-closed state. Neither of two groups was taking medicines. All artificial epochs in the EEG records were rejected by an experienced doctor's visual inspection. Testing non-linearity with modified surrogate data, we showed that correlation dimension of EEG data of schizophrenia does refuse the null hypothesis that the data were resulted from a linear dynamic system. A decrease of dimension complexity was found in the EEG of schizophrenia compared with controls. We interpreted it as the result of the psychopath's dysfunction overall brain. The surrogating procedure results in a significant increase in D(s). Non-linearity of the EEG in schizophrenia was proven in our study. We think the correlation dimension with spatial embedding as a good discriminating statistic for testing such non-linearity. Moreover, schizophrenic patients' EEGs were compared with controls and a lower dimension complexity was found. The results of our study indicate the possibility of using the methods of non-linear time series analysis to identify the EEGs of schizophrenic patients.
doi_str_mv 10.1016/S1388-2457(01)00544-2
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Adult
Algorithms
Analysis of Variance
Biological and medical sciences
Electrodiagnosis. Electric activity recording
Electroencephalography
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Nervous system
Nonlinear Dynamics
Pilot Projects
Schizophrenia - physiopathology
title Detection of non-linearity in the EEG of schizophrenic patients
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