ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films

In vivo, chondrocytes are surrounded by an extracellular matrix, preventing direct cell-to-cell contact. Consequently, intercellular communication through gap junctions is unlikely. However, signaling at a distance is possible through extracellular messengers such as nitric oxide (NO) and nucleotide...

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Veröffentlicht in:	Osteoarthritis and cartilage 2001-08, Vol.9 (6), p.518-526
Hauptverfasser:	Elfervig, M K, Graff, R D, Lee, G M, Kelley, S S, Sood, A, Banes, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - physiology Adenosine Triphosphate - physiology Antineoplastic Agents - pharmacology Calcium Signaling - physiology Cells, Cultured Chondrocytes - physiology Dose-Response Relationship, Drug Fura-2 Humans Sepharose Suramin - pharmacology Uridine Triphosphate - physiology
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