A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder
Background: Adult posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volumes; however, decreased hippocampal volumes were not seen in pediatric maltreatment-related PTSD. We examined hippocampal volumes longitudinally to determine if a history of childhood traumatic stress...
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| Veröffentlicht in: | Biological psychiatry (1969) 2001-08, Vol.50 (4), p.305-309 |
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| container_title | Biological psychiatry (1969) |
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| creator | De Bellis, Michael D Hall, Julie Boring, Amy M Frustaci, Karin Moritz, Grace |
| description | Background: Adult posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volumes; however, decreased hippocampal volumes were not seen in pediatric maltreatment-related PTSD. We examined hippocampal volumes longitudinally to determine if a history of childhood traumatic stress alters hippocampal growth during puberty.
Methods: Magnetic resonance imaging was used to measure temporal lobes, amygdala, and hippocampal volumes in nine prepubertal maltreated subjects with pediatric maltreatment-related PTSD and nine sociodemographically matched healthy nonmaltreated yoked control subjects at baseline and after at least 2 years follow-up (during the later stages of pubertal development) using identical equipment and measurement methodology.
Results: Temporal lobe, amygdala and hippocampal volumes did not differ between groups at baseline, follow-up, or across time.
Conclusions: Whereas these data are from a small sample, the results do not support hippocampal changes in pediatric maltreatment-related PTSD. |
| doi_str_mv | 10.1016/S0006-3223(01)01105-2 |
| format | Article |
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Methods: Magnetic resonance imaging was used to measure temporal lobes, amygdala, and hippocampal volumes in nine prepubertal maltreated subjects with pediatric maltreatment-related PTSD and nine sociodemographically matched healthy nonmaltreated yoked control subjects at baseline and after at least 2 years follow-up (during the later stages of pubertal development) using identical equipment and measurement methodology.
Results: Temporal lobe, amygdala and hippocampal volumes did not differ between groups at baseline, follow-up, or across time.
Conclusions: Whereas these data are from a small sample, the results do not support hippocampal changes in pediatric maltreatment-related PTSD.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(01)01105-2</identifier><identifier>PMID: 11522266</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; amygdala ; Amygdala - anatomy & histology ; Amygdala - physiology ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Child ; Child Abuse - psychology ; Child maltreatment ; Child, Preschool ; Female ; Follow-Up Studies ; hippocampus ; Hippocampus - abnormalities ; Hippocampus - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; neurodevelopment ; Panic disorder ; Pilot Projects ; posttraumatic stress disorder ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Stress Disorders, Post-Traumatic - diagnosis ; Stress Disorders, Post-Traumatic - physiopathology ; Stress Disorders, Post-Traumatic - psychology ; Temporal Lobe - anatomy & histology ; Temporal Lobe - physiology</subject><ispartof>Biological psychiatry (1969), 2001-08, Vol.50 (4), p.305-309</ispartof><rights>2001 Society of Biological Psychiatry</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-90a12321eb76388cd4bab1548ddc13c10f4717811284ca9b2e023eccf5f0c0a3</citedby><cites>FETCH-LOGICAL-c403t-90a12321eb76388cd4bab1548ddc13c10f4717811284ca9b2e023eccf5f0c0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(01)01105-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14066675$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11522266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Bellis, Michael D</creatorcontrib><creatorcontrib>Hall, Julie</creatorcontrib><creatorcontrib>Boring, Amy M</creatorcontrib><creatorcontrib>Frustaci, Karin</creatorcontrib><creatorcontrib>Moritz, Grace</creatorcontrib><title>A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: Adult posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volumes; however, decreased hippocampal volumes were not seen in pediatric maltreatment-related PTSD. We examined hippocampal volumes longitudinally to determine if a history of childhood traumatic stress alters hippocampal growth during puberty.
Methods: Magnetic resonance imaging was used to measure temporal lobes, amygdala, and hippocampal volumes in nine prepubertal maltreated subjects with pediatric maltreatment-related PTSD and nine sociodemographically matched healthy nonmaltreated yoked control subjects at baseline and after at least 2 years follow-up (during the later stages of pubertal development) using identical equipment and measurement methodology.
Results: Temporal lobe, amygdala and hippocampal volumes did not differ between groups at baseline, follow-up, or across time.
Conclusions: Whereas these data are from a small sample, the results do not support hippocampal changes in pediatric maltreatment-related PTSD.</description><subject>Adult and adolescent clinical studies</subject><subject>amygdala</subject><subject>Amygdala - anatomy & histology</subject><subject>Amygdala - physiology</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Abuse - psychology</subject><subject>Child maltreatment</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>hippocampus</subject><subject>Hippocampus - abnormalities</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>neurodevelopment</subject><subject>Panic disorder</subject><subject>Pilot Projects</subject><subject>posttraumatic stress disorder</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Stress Disorders, Post-Traumatic - diagnosis</subject><subject>Stress Disorders, Post-Traumatic - physiopathology</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Temporal Lobe - anatomy & histology</subject><subject>Temporal Lobe - physiology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtrFTEUwPEgir2tfgQlG0UXo-dknndVSrEqFFzYfTiTnNFIZjJNMoV-e9Pei126yoNfHvyFeIPwCQG7zz8BoKtqpeoPgB8BEdpKPRM7HPq6Ug2o52L3j5yI05T-lGWvFL4UJ4itUqrrduL2Qq7Ohyx9WH65vFm3kJepTO5lmORvt67B0LyWzbvgt5mTdItc2TrK0Rk5k8-RKc-85Cqyp8xWriHlHGmbKReSCkhJWpdCtBxfiRcT-cSvj-OZuLn6cnP5rbr-8fX75cV1ZRqoc7UHQlUr5LHv6mEwthlpxLYZrDVYG4Sp6bEfENXQGNqPikHVbMzUTmCA6jPx_nDtGsPtxinr2SXD3tPCYUu6R8RBwb7A9gBNDClFnvQa3UzxXiPoh9T6MbV-6KgB9WNqrcq5t8cHtnFm-3Tq2LaAd0dAyZCfIi3GpSfXQNd1fVvc-cFxqXHnOOpkHC-mNI5ssrbB_ecrfwE6K50g</recordid><startdate>20010815</startdate><enddate>20010815</enddate><creator>De Bellis, Michael D</creator><creator>Hall, Julie</creator><creator>Boring, Amy M</creator><creator>Frustaci, Karin</creator><creator>Moritz, Grace</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010815</creationdate><title>A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder</title><author>De Bellis, Michael D ; Hall, Julie ; Boring, Amy M ; Frustaci, Karin ; Moritz, Grace</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-90a12321eb76388cd4bab1548ddc13c10f4717811284ca9b2e023eccf5f0c0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult and adolescent clinical studies</topic><topic>amygdala</topic><topic>Amygdala - anatomy & histology</topic><topic>Amygdala - physiology</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Abuse - psychology</topic><topic>Child maltreatment</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>hippocampus</topic><topic>Hippocampus - abnormalities</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>neurodevelopment</topic><topic>Panic disorder</topic><topic>Pilot Projects</topic><topic>posttraumatic stress disorder</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Stress Disorders, Post-Traumatic - diagnosis</topic><topic>Stress Disorders, Post-Traumatic - physiopathology</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Temporal Lobe - anatomy & histology</topic><topic>Temporal Lobe - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Bellis, Michael D</creatorcontrib><creatorcontrib>Hall, Julie</creatorcontrib><creatorcontrib>Boring, Amy M</creatorcontrib><creatorcontrib>Frustaci, Karin</creatorcontrib><creatorcontrib>Moritz, Grace</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Bellis, Michael D</au><au>Hall, Julie</au><au>Boring, Amy M</au><au>Frustaci, Karin</au><au>Moritz, Grace</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2001-08-15</date><risdate>2001</risdate><volume>50</volume><issue>4</issue><spage>305</spage><epage>309</epage><pages>305-309</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: Adult posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volumes; however, decreased hippocampal volumes were not seen in pediatric maltreatment-related PTSD. We examined hippocampal volumes longitudinally to determine if a history of childhood traumatic stress alters hippocampal growth during puberty.
Methods: Magnetic resonance imaging was used to measure temporal lobes, amygdala, and hippocampal volumes in nine prepubertal maltreated subjects with pediatric maltreatment-related PTSD and nine sociodemographically matched healthy nonmaltreated yoked control subjects at baseline and after at least 2 years follow-up (during the later stages of pubertal development) using identical equipment and measurement methodology.
Results: Temporal lobe, amygdala and hippocampal volumes did not differ between groups at baseline, follow-up, or across time.
Conclusions: Whereas these data are from a small sample, the results do not support hippocampal changes in pediatric maltreatment-related PTSD.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11522266</pmid><doi>10.1016/S0006-3223(01)01105-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies amygdala Amygdala - anatomy & histology Amygdala - physiology Anxiety disorders. Neuroses Biological and medical sciences Child Child Abuse - psychology Child maltreatment Child, Preschool Female Follow-Up Studies hippocampus Hippocampus - abnormalities Hippocampus - physiopathology Humans Magnetic Resonance Imaging Male Medical sciences neurodevelopment Panic disorder Pilot Projects posttraumatic stress disorder Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Stress Disorders, Post-Traumatic - diagnosis Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology Temporal Lobe - anatomy & histology Temporal Lobe - physiology |
| title | A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder |
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