Structure of Cruzipain/Cruzain Inhibitors Isolated from Bauhinia bauhinioides Seeds

The saline extract of Bauhinia bauhinioides dry seeds was shown to inhibit cruzipain, a cysteine proteinase from Trypanosoma cruzi. The inhibitory activity was assigned to a protein with 164 amino acid residues and molecular mass of 18 034 Da that was purified by chromatography on DEAESephadex, tryp...

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Veröffentlicht in:	Biological chemistry 2001-05, Vol.382 (5), p.847-852
Hauptverfasser:	Oliveira, C. de, Santana, L.A., Carmona, A.K., Cezari, M.H., Sampaio, M.U., Sampaio, C.A.M., Oliva, M.L.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cysteine Endopeptidases - drug effects Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - isolation & purification Kinetics Molecular Sequence Data Molecular Structure Plant Proteins - chemistry Plant Proteins - isolation & purification Protozoan Proteins - antagonists & inhibitors Seeds - chemistry Sequence Alignment
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