Infection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1

A number of diseases affecting the CNS occur in the dog and can be used as models for gene therapy in a large brain. HSV-1 has several potential advantages as a vector to transfer genes into the CNS. However, the ability of HSV-1 to infect CNS cells varies among species and no information was availa...

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Veröffentlicht in:	Journal of neurovirology 2001-04, Vol.7 (2), p.149-154
1. Verfasser:	Sandra L Springer, Charles H Vite, Ara C Polesky, Santosh Kesari, Nigel W Fraser, John H Wolfe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - pathology Brain - virology Disease Models, Animal Dogs Encephalitis, Herpes Simplex - pathology Encephalitis, Herpes Simplex - virology Genetic Therapy - methods Genetic Vectors Herpes simplex virus 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - pathogenicity Male Virulence
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container_title	Journal of neurovirology
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creator	Sandra L Springer, Charles H Vite, Ara C Polesky, Santosh Kesari, Nigel W Fraser, John H Wolfe
description	A number of diseases affecting the CNS occur in the dog and can be used as models for gene therapy in a large brain. HSV-1 has several potential advantages as a vector to transfer genes into the CNS. However, the ability of HSV-1 to infect CNS cells varies among species and no information was available for the dog. When the nonpathogenic 1716 strain of HSV-1 was injected into the brains of normal dogs it established a latent infection without signs of pathology. Thus, it appears to be suitable as a vector for therapeutic, or marker genes, in this species.
doi_str_mv	10.1080/13550280152058807
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subjects	Animals Brain - pathology Brain - virology Disease Models, Animal Dogs Encephalitis, Herpes Simplex - pathology Encephalitis, Herpes Simplex - virology Genetic Therapy - methods Genetic Vectors Herpes simplex virus 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - pathogenicity Male Virulence
title	Infection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1
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