PTEN mutation analysis in two genetic subtypes of high-grade oligodendroglial tumors. PTEN is only occasionally mutated in one of the two genetic subtypes
We recently identified two genetic subtypes of high-grade oligodendroglial tumors (HG-OT): 1p-/19q- HG-OT are characterized by a loss of chromosome 1p32-36 (del(1)(p32-p36) and/or a del(19)(q13. 3); whereas +7/-10 HG-OT harbor a gain of chromosome 7 (+7) and/or a -10 without a loss of 1p32-36 and 19...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2000-05, Vol.119 (1), p.42-47 |
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| creator | Jeuken, J W Nelen, M R Vermeer, H van Staveren, W C Kremer, H van Overbeeke, J J Boerman, R H |
| description | We recently identified two genetic subtypes of high-grade oligodendroglial tumors (HG-OT): 1p-/19q- HG-OT are characterized by a loss of chromosome 1p32-36 (del(1)(p32-p36) and/or a del(19)(q13. 3); whereas +7/-10 HG-OT harbor a gain of chromosome 7 (+7) and/or a -10 without a loss of 1p32-36 and 19q13.3. Because a -10 and a +7 are most frequently detected in glioblastomas (GBM), the genotype of +7/-10 HG-OT suggests that these tumors are GBM with a prominent oligodendroglial phenotype rather than anaplastic oligodendrogliomas. PTEN is a tumor suppressor gene, located at 10q23.3, which is involved in tumor progression of GBM and other neoplasms. In this study, we screened for PTEN mutations in six low-grade oligodendroglial tumors (LG-OT), five 1p-/19q- HG-OT, seven +7/-10 HG-OT, and nine xenografted GBM. PTEN mutations were detected in none of the LG-OT and 1p-/19q- HG-OT, once in +7/-10 HG-OT, and frequently in GBM. As one of the +7/-10 HG-OT harbored a PTEN mutation, this demonstrates that PTEN can be involved in the oncogenesis of this genetic subtype of HG-OT. The lower frequency of PTEN mutations in +7/-10 HG-OT compared to GBM suggests that these tumors are of a distinct tumor type rather than GBM. Published by Elsevier Science Inc. |
| doi_str_mv | 10.1016/S0165-4608(99)00210-1 |
| format | Article |
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PTEN is only occasionally mutated in one of the two genetic subtypes</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Jeuken, J W ; Nelen, M R ; Vermeer, H ; van Staveren, W C ; Kremer, H ; van Overbeeke, J J ; Boerman, R H</creator><creatorcontrib>Jeuken, J W ; Nelen, M R ; Vermeer, H ; van Staveren, W C ; Kremer, H ; van Overbeeke, J J ; Boerman, R H</creatorcontrib><description>We recently identified two genetic subtypes of high-grade oligodendroglial tumors (HG-OT): 1p-/19q- HG-OT are characterized by a loss of chromosome 1p32-36 (del(1)(p32-p36) and/or a del(19)(q13. 3); whereas +7/-10 HG-OT harbor a gain of chromosome 7 (+7) and/or a -10 without a loss of 1p32-36 and 19q13.3. Because a -10 and a +7 are most frequently detected in glioblastomas (GBM), the genotype of +7/-10 HG-OT suggests that these tumors are GBM with a prominent oligodendroglial phenotype rather than anaplastic oligodendrogliomas. PTEN is a tumor suppressor gene, located at 10q23.3, which is involved in tumor progression of GBM and other neoplasms. In this study, we screened for PTEN mutations in six low-grade oligodendroglial tumors (LG-OT), five 1p-/19q- HG-OT, seven +7/-10 HG-OT, and nine xenografted GBM. PTEN mutations were detected in none of the LG-OT and 1p-/19q- HG-OT, once in +7/-10 HG-OT, and frequently in GBM. As one of the +7/-10 HG-OT harbored a PTEN mutation, this demonstrates that PTEN can be involved in the oncogenesis of this genetic subtype of HG-OT. The lower frequency of PTEN mutations in +7/-10 HG-OT compared to GBM suggests that these tumors are of a distinct tumor type rather than GBM. 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PTEN is only occasionally mutated in one of the two genetic subtypes</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>We recently identified two genetic subtypes of high-grade oligodendroglial tumors (HG-OT): 1p-/19q- HG-OT are characterized by a loss of chromosome 1p32-36 (del(1)(p32-p36) and/or a del(19)(q13. 3); whereas +7/-10 HG-OT harbor a gain of chromosome 7 (+7) and/or a -10 without a loss of 1p32-36 and 19q13.3. Because a -10 and a +7 are most frequently detected in glioblastomas (GBM), the genotype of +7/-10 HG-OT suggests that these tumors are GBM with a prominent oligodendroglial phenotype rather than anaplastic oligodendrogliomas. PTEN is a tumor suppressor gene, located at 10q23.3, which is involved in tumor progression of GBM and other neoplasms. In this study, we screened for PTEN mutations in six low-grade oligodendroglial tumors (LG-OT), five 1p-/19q- HG-OT, seven +7/-10 HG-OT, and nine xenografted GBM. PTEN mutations were detected in none of the LG-OT and 1p-/19q- HG-OT, once in +7/-10 HG-OT, and frequently in GBM. As one of the +7/-10 HG-OT harbored a PTEN mutation, this demonstrates that PTEN can be involved in the oncogenesis of this genetic subtype of HG-OT. The lower frequency of PTEN mutations in +7/-10 HG-OT compared to GBM suggests that these tumors are of a distinct tumor type rather than GBM. Published by Elsevier Science Inc.</description><subject>Brain Neoplasms - classification</subject><subject>Brain Neoplasms - genetics</subject><subject>Humans</subject><subject>Mutation</subject><subject>Nucleic Acid Hybridization</subject><subject>Oligodendroglioma - classification</subject><subject>Oligodendroglioma - genetics</subject><subject>Phosphoric Monoester Hydrolases - genetics</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>PTEN Phosphohydrolase</subject><subject>Tumor Suppressor Proteins</subject><issn>0165-4608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtOwzAQRb0A0VL4BJBXCBaBcR5NskRVeUgVIFHWkR1PUiPHDrEjlF_ha0lLYcVmRjO6OkczhJwxuGbA5jevY0mCeA7ZZZ5fAYQMAnZApn_rCTl27h0A0jCfH5EJg4yFLIUp-XpZL59o03vulTWUG64HpxxVhvpPS2s06FVJXS_80KKjtqIbVW-CuuMSqdWqthKN7GytFdfU943t3DXdUUeMNXqgtiy5G-lcj8NOhXIrsAa3PL_Bf10n5LDi2uHpvs_I291yvXgIVs_3j4vbVdCGkPogKfMYpYgSgRmvUplHJRMSGEhAkPl4cpRJmcVSMB5lUYgCeBgLFBxkXGVxNCMXP9y2sx89Ol80ypWoNTdoe1ekjLEkhnQMnu-DvWhQFm2nGt4Nxe83o2-t0XmD</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Jeuken, J W</creator><creator>Nelen, M R</creator><creator>Vermeer, H</creator><creator>van Staveren, W C</creator><creator>Kremer, H</creator><creator>van Overbeeke, J J</creator><creator>Boerman, R H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200005</creationdate><title>PTEN mutation analysis in two genetic subtypes of high-grade oligodendroglial tumors. 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PTEN is only occasionally mutated in one of the two genetic subtypes</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2000-05</date><risdate>2000</risdate><volume>119</volume><issue>1</issue><spage>42</spage><epage>47</epage><pages>42-47</pages><issn>0165-4608</issn><abstract>We recently identified two genetic subtypes of high-grade oligodendroglial tumors (HG-OT): 1p-/19q- HG-OT are characterized by a loss of chromosome 1p32-36 (del(1)(p32-p36) and/or a del(19)(q13. 3); whereas +7/-10 HG-OT harbor a gain of chromosome 7 (+7) and/or a -10 without a loss of 1p32-36 and 19q13.3. Because a -10 and a +7 are most frequently detected in glioblastomas (GBM), the genotype of +7/-10 HG-OT suggests that these tumors are GBM with a prominent oligodendroglial phenotype rather than anaplastic oligodendrogliomas. PTEN is a tumor suppressor gene, located at 10q23.3, which is involved in tumor progression of GBM and other neoplasms. In this study, we screened for PTEN mutations in six low-grade oligodendroglial tumors (LG-OT), five 1p-/19q- HG-OT, seven +7/-10 HG-OT, and nine xenografted GBM. PTEN mutations were detected in none of the LG-OT and 1p-/19q- HG-OT, once in +7/-10 HG-OT, and frequently in GBM. As one of the +7/-10 HG-OT harbored a PTEN mutation, this demonstrates that PTEN can be involved in the oncogenesis of this genetic subtype of HG-OT. The lower frequency of PTEN mutations in +7/-10 HG-OT compared to GBM suggests that these tumors are of a distinct tumor type rather than GBM. Published by Elsevier Science Inc.</abstract><cop>United States</cop><pmid>10812170</pmid><doi>10.1016/S0165-4608(99)00210-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Brain Neoplasms - classification Brain Neoplasms - genetics Humans Mutation Nucleic Acid Hybridization Oligodendroglioma - classification Oligodendroglioma - genetics Phosphoric Monoester Hydrolases - genetics Polymorphism, Single-Stranded Conformational PTEN Phosphohydrolase Tumor Suppressor Proteins |
| title | PTEN mutation analysis in two genetic subtypes of high-grade oligodendroglial tumors. PTEN is only occasionally mutated in one of the two genetic subtypes |
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