Involvement of Heparin-Binding EGF-like Growth Factor and Its Processing by Metalloproteinases in Early Epithelial Morphogenesis of the Submandibular Gland

In the present study, the role of a member of the epidermal growth factor (EGF) family, heparin-binding EGF-like growth factor (HB-EGF), in organ development was investigated by using developing mouse submandibular gland (SMG), in which the EGF receptor signaling and heparan sulfate chains have been...

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Veröffentlicht in:	Developmental biology 2001-09, Vol.237 (1), p.202-211
Hauptverfasser:	Umeda, Yuko, Miyazaki, Yuji, Shiinoki, Hiroko, Higashiyama, Shigeki, Nakanishi, Yasuo, Hieda, Yohki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals EGF receptor Epidermal Growth Factor - physiology HB-EGF heparan sulfate proteoglycan Heparin-binding EGF-like Growth Factor Intercellular Signaling Peptides and Proteins Metalloendopeptidases - physiology metalloproteinase Mice Molecular Sequence Data Morphogenesis mouse Organ Culture Techniques Protease Inhibitors - pharmacology Receptor, Epidermal Growth Factor - physiology submandibular gland Submandibular Gland - embryology
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