Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase
We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). Because colorectal me...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (9), p.2365-2367 |
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| creator | BANERJEE, D GORLICK, R KEMENY, N BERTINO, J. R LIEFSHITZ, A DANENBERG, K DANENBERG, P. C DANENBERG, P. V KLIMSTRA, D JHANWAR, S CORDON-CARDO, C FONG, Y |
| description | We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). Because colorectal metastasis to the lung has higher TS levels than liver metastasis and is less responsive to treatment with 5-fluorouracil (R. Gorlick et al., J. Clin. Oncol., 16: 1465-1469, 1998), it was, therefore, of interest to measure E2F-1 expression in these tumors. In contrast to marginally increased levels of dihydrofolate reductase and topoisomerase I in lung metastasis as compared with liver metastasis, lung tumors had a 5-fold increase in E2F-1 expression as compared with liver tumors, corresponding to the relative levels of TS in these metastases. These data indicate that there exists a close correlation between E2F-1 and TS levels and provide a rationale for targeting this transcription factor, ie., E2F-1, for the treatment of certain cancers. |
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R ; LIEFSHITZ, A ; DANENBERG, K ; DANENBERG, P. C ; DANENBERG, P. V ; KLIMSTRA, D ; JHANWAR, S ; CORDON-CARDO, C ; FONG, Y</creator><creatorcontrib>BANERJEE, D ; GORLICK, R ; KEMENY, N ; BERTINO, J. R ; LIEFSHITZ, A ; DANENBERG, K ; DANENBERG, P. C ; DANENBERG, P. V ; KLIMSTRA, D ; JHANWAR, S ; CORDON-CARDO, C ; FONG, Y</creatorcontrib><description>We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). Because colorectal metastasis to the lung has higher TS levels than liver metastasis and is less responsive to treatment with 5-fluorouracil (R. Gorlick et al., J. Clin. Oncol., 16: 1465-1469, 1998), it was, therefore, of interest to measure E2F-1 expression in these tumors. In contrast to marginally increased levels of dihydrofolate reductase and topoisomerase I in lung metastasis as compared with liver metastasis, lung tumors had a 5-fold increase in E2F-1 expression as compared with liver tumors, corresponding to the relative levels of TS in these metastases. These data indicate that there exists a close correlation between E2F-1 and TS levels and provide a rationale for targeting this transcription factor, ie., E2F-1, for the treatment of certain cancers.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 10811110</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenocarcinoma - metabolism ; Biological and medical sciences ; Blotting, Western ; Carrier Proteins ; Cell Cycle Proteins ; Colonic Neoplasms - pathology ; DNA-Binding Proteins ; E2F Transcription Factors ; E2F-1 protein ; E2F1 Transcription Factor ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Liver Neoplasms - metabolism ; Liver Neoplasms - secondary ; Lung Neoplasms - metabolism ; Lung Neoplasms - secondary ; Medical sciences ; Retinoblastoma-Binding Protein 1 ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Thymidylate Synthase - biosynthesis ; Transcription Factor DP1 ; Transcription Factors - biosynthesis ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2000-05, Vol.60 (9), p.2365-2367</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1453300$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10811110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANERJEE, D</creatorcontrib><creatorcontrib>GORLICK, R</creatorcontrib><creatorcontrib>KEMENY, N</creatorcontrib><creatorcontrib>BERTINO, J. 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Because colorectal metastasis to the lung has higher TS levels than liver metastasis and is less responsive to treatment with 5-fluorouracil (R. Gorlick et al., J. Clin. Oncol., 16: 1465-1469, 1998), it was, therefore, of interest to measure E2F-1 expression in these tumors. In contrast to marginally increased levels of dihydrofolate reductase and topoisomerase I in lung metastasis as compared with liver metastasis, lung tumors had a 5-fold increase in E2F-1 expression as compared with liver tumors, corresponding to the relative levels of TS in these metastases. These data indicate that there exists a close correlation between E2F-1 and TS levels and provide a rationale for targeting this transcription factor, ie., E2F-1, for the treatment of certain cancers.</description><subject>Adenocarcinoma - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Carrier Proteins</subject><subject>Cell Cycle Proteins</subject><subject>Colonic Neoplasms - pathology</subject><subject>DNA-Binding Proteins</subject><subject>E2F Transcription Factors</subject><subject>E2F-1 protein</subject><subject>E2F1 Transcription Factor</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - secondary</subject><subject>Medical sciences</subject><subject>Retinoblastoma-Binding Protein 1</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Thymidylate Synthase - biosynthesis</subject><subject>Transcription Factor DP1</subject><subject>Transcription Factors - biosynthesis</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOxCAUhonROOPoKxgWxl0TKFA6SzMZL8kkbnTdUDidYuhFaNW-jM8qmRkvO09Izu37IfxHaE4FyxPJuThGc0JInggu0xk6C-EltoIScYpmlOQ0Bpmjzw28gQu4q_A6vU0oho_eQwi2a7HygGu7rcFj22I3tlvcwKBCPHan0J2LmFatjogKsW_6KDL43Q41rqFXg9V_Nao1EfIenBpgT7mf94d6aqyZdqswtUOtApyjk0q5ABeHvEDPt-un1X2yebx7WN1skpoRMiRZVnKWVZBnXJWxYJQZAppWQhuQOqVluizjKNWcZpJJY2jGS77MZKmNLiVboOv9vb3vXkcIQ9HYoME51UI3hkJGt9gyE_-CVAqeR8cjeHkAx7IBU_TeNspPxbf1Ebg6ACpo5SofbbThl-OCxb-xLwTvkBY</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>BANERJEE, D</creator><creator>GORLICK, R</creator><creator>KEMENY, N</creator><creator>BERTINO, J. 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Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - secondary</topic><topic>Medical sciences</topic><topic>Retinoblastoma-Binding Protein 1</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Thymidylate Synthase - biosynthesis</topic><topic>Transcription Factor DP1</topic><topic>Transcription Factors - biosynthesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BANERJEE, D</creatorcontrib><creatorcontrib>GORLICK, R</creatorcontrib><creatorcontrib>KEMENY, N</creatorcontrib><creatorcontrib>BERTINO, J. R</creatorcontrib><creatorcontrib>LIEFSHITZ, A</creatorcontrib><creatorcontrib>DANENBERG, K</creatorcontrib><creatorcontrib>DANENBERG, P. 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V</au><au>KLIMSTRA, D</au><au>JHANWAR, S</au><au>CORDON-CARDO, C</au><au>FONG, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>60</volume><issue>9</issue><spage>2365</spage><epage>2367</epage><pages>2365-2367</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). 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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenocarcinoma - metabolism Biological and medical sciences Blotting, Western Carrier Proteins Cell Cycle Proteins Colonic Neoplasms - pathology DNA-Binding Proteins E2F Transcription Factors E2F-1 protein E2F1 Transcription Factor Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Liver Neoplasms - metabolism Liver Neoplasms - secondary Lung Neoplasms - metabolism Lung Neoplasms - secondary Medical sciences Retinoblastoma-Binding Protein 1 Reverse Transcriptase Polymerase Chain Reaction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thymidylate Synthase - biosynthesis Transcription Factor DP1 Transcription Factors - biosynthesis Tumors |
| title | Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase |
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