TAJ, a Novel Member of the Tumor Necrosis Factor Receptor Family, Activates the c-Jun N-terminal Kinase Pathway and Mediates Caspase-independent Cell Death

We have isolated a novel member of the TNFR family, designated TAJ, that is highly expressed during embryonic development. TAJ possesses a unique cytoplasmic domain with no sequence homology to the previously characterized members of the TNFR family. TAJ interacts with the TRAF family members and ac...

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Veröffentlicht in:	The Journal of biological chemistry 2000-05, Vol.275 (20), p.15336-15342
Hauptverfasser:	Eby, Michael T., Jasmin, Alan, Kumar, Arvind, Sharma, Kiran, Chaudhary, Preet M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Caspases - metabolism Cell Death Cell Line Cloning, Molecular Embryonic and Fetal Development Female Gene Expression Regulation, Developmental Humans JNK Mitogen-Activated Protein Kinases Male Mice Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data Organ Specificity Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Sequence Alignment Sequence Homology, Amino Acid
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